摘要
目的探讨巨细胞病毒感染婴儿中人巨细胞病毒母乳感染率及意义。方法应用荧光定量PCR法检测124例确诊巨细胞病毒感染患儿母亲的母乳和全血中HCMV-DNA含量,并同时测定母亲血浆中HCMV-IgM。结果 FQ-PCR检测HCMVDNA乳汁的阳性率为69.4%,全血的阳性率为23.4%;HCMV-IgM阳性率27.4%。母乳HCMV-DNA的阳性率明显高于全血HCMV-DNA及特异性抗体IgM的阳性率(P<0.05)。结论感染巨细胞病毒患儿的母乳中带毒率高,母乳感染HCMV可能是婴儿获得性巨细胞感染的主要途径。
Objective To investigate HCMV infection rate and meaning in breast milk of CMV infected infant＇s mother. Methods Fluorescent quantitative PCR was used to detect HCMV-DNA in breast milk and whole blood of 124 mother of HCMV infected infants , and ELISA was used to detect HCMV-IgM in mothers＇ blood. Results The positive rate of HCMV DNA in breast milk was 69.4%,in blood was 23.4%; the positive rate of HCMV-IgM was 27.4%. The positive rate of HCMV DNA in breast milk was significantly higher than whole blood and HCMV-IgM（P 〈 0.05）. Conclusion The positive rate of HCMV-DNA in breast milk was high. Breast milk is the important in transmission of HCMV infection.
出处
《中国医药科学》
2012年第17期120-120,126,共2页
China Medicine And Pharmacy
