期刊文献+

肝脏肿瘤基因治疗策略及其前景展望

暂未订购
导出
摘要 肿瘤目前已成为危害人类身体健康的最大杀手,对于其发病机理一直是医学科研工作者的公关难题.经过大量的实验和理论推断,人们在肿瘤的发病机理上得出多种假设,其中科学界叫认同的是基因突变、免疫监视、细胞反分化等3种假说,随着基因组学的研究发展,肿瘤基因突变学说备受学者们的关注.
作者 谢玲林
出处 《中国社区医师(医学专业)》 2012年第24期62-62,共1页
  • 相关文献

参考文献7

  • 1张峰,霍金龙,曾养志.基因治疗的应用及研究进展[J].生物技术通讯,2007,18(4):677-679. 被引量:6
  • 2Liu G,Chen X. The C - term in al sterile aim phamot if and the extreme C terminus regulate the transcriptional activity of the alpha isoform of W3 [ J]. J Biol Chem,2005,280 (2(1) : 20111 -20119.
  • 3Tepper RI , Mulle JJ. Experimental and clinical studies of cytokine gene - modified tumor cells. Human Gene Ther,1994,5:153- 164.
  • 4Ausubel FM,Brent R,Kingdom RE,et al. Cur- rent Protocolsin Molecular Biology [ M ]. New York: Greene Publishing Associates, Inc. & John Wiley & Sons, Inc ,2004:224 - 227.
  • 5Park T, Hcmando K, Kubler T, et al. A phase I study of vaccination with tumor cells in pa- tients with ad,Janced gynecological cancers [ J ]. Thirty seventh Annual Meeting : Ameri- can Society of Clinical Onoology,2001,1074: 269.
  • 6柳洁,谢正兰,吴和平,饶利兵.肿瘤基因治疗的现状与展望[J].肿瘤药学,2011,1(3):166-168. 被引量:6
  • 7宋海珠,罗荣城,姜波.肿瘤基因治疗的研究进展和展望[J].解放军医学杂志,2002,27(7):651-652. 被引量:5

二级参考文献21

  • 1Anderson W.Human genetherapy[J].Science,1992,256:808.
  • 2Krepper F,Luther T,Semkova I,et al.Long-term transgene expression in the RPE after gene transfer with a high-capacity adenovirus certor[J].Invest Ophthalmol Vis Sci,2002,43(6):1965.
  • 3Blae S,Culver J,Miller L,et al.T-lyipho-cyte-direeted gene therapy or ADA-SCID:initialtrial results after 4 years[J].Science,1995,270:475.
  • 4Anderson W.Human genetherapy[J].Nature,1998,392:25.
  • 5Annette K,Guo S,Li F,et al.Controllable self-assembly of nanoparticies for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanolechnology[J].Nano Lett,2005,5(9):1797.
  • 6Novina CD,Murray MF,Dykxhoorn DM,et al.siRNA-directed inhibition of HIV-1 infection[J].Nat Med,2002,8(7):681.
  • 7Akkina R,Baneriea A,Bai J,et al.siRNAs ribozymes and RNA decoys in modeling stem cell-based gene therapy for HIV/AIDS.Anticancer Res,2003,23(3A):1997.
  • 8Soutschek J,Akinc A,Bramage B,et al.Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs[J].Nature,2004,432(7014):173.
  • 9Zender L,Hutker S,Liedtke C,et al.Caspase 8 small interfering RNA prevents acute liver failure in mice[J].Proc Nat Acad Sci USA,2003,100:7797.
  • 10Song E,Lee SK,Wang J,et al.RNA interference targeting Fas protects mice from fulminant hepatitis[J].Nat Med,2003,9:347.

共引文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部