摘要
顺铂(DDP)是目前世界上治疗恶性肿瘤的重要药物之一。但是,由于严重的消化道反应和肾、耳神经毒性限制了它在临床上的应用范围。八十年代初国外开始研究第二代铂络化合物——碳铂(Carboplatin CBDCA),经临床前及临床研究该药抗瘤谱广,对多数肿瘤的抗肿瘤活性与顺铂相似,且尚未发现类似顺铂对肾和高频区听力的损伤。恶心呕吐等消化道反应较轻.
Thirty two cases of cytopathologically confirmed advanced lung cancer were treatedwith Carboplatine (320mg/m^2/d) and Etoposide (150mg/m^2/d). In 13 SCLO cases, 6gained complete remission, 5 partial remission; and in 19 N-SCLC cases, 2 cases withCR and 3 with PR. Rates of response were 84. 6% and 26 .3% respectively. The myelo-suppressive toxicity was reversible. Gastrointestinal reactions were mild. None of thecases had been interrupted in their course of treatment.
出处
《肿瘤》
CAS
CSCD
北大核心
1990年第6期253-254,共2页
Tumor
