摘要
应用高效液相色谱法（ＨＰＬＣ）对６只犬体内碳铂腹腔内给药药代动力学进行研究。碳铂３０ｍｇ／ｋｇ加生理盐水５００ｍｌ，快速腹腔给药，不同时间取腹腔液、门静脉及股静脉血测定总铂浓度。结果表明大剂量、大容量碳铂经腹腔给药后２４０ｍｉｎ内腹腔浓度最高，峰值浓度和平均浓度分别为股静脉浓度１３９倍和６４倍；门静脉次之，分别为股静脉浓度１３．３倍和６．５倍。碳铂腹腔给药在腹腔、门静脉和肝脏提供恒定持久的高药物浓度，大大提高了抗癌药对肿瘤细胞的杀伤作用，减少到达体循环量，从而减轻了全身毒副作用。对胃肠道恶性肿瘤术后腹腔复发癌和肝转移癌预防和治疗颇有意义。
High performance liguid chromatography was used to study the performances of carboplatin intraperitoneal (ip) administration in six dogs. 30mg/kg carboplatin added 500ml 0.9%sodium chloride was injected ip quickly.Drug levels of peritoneal fluid and blood of the protal vein and femoral vein were measured in different time The results showed that drug concentration in peritoneal fluid is the highest in 240 minutes after large dose and volume carboplatin administered ip.The peak and mean concentrations of the peritoneal fluid were 139 and 64 times than that of blood in the femoral vein, respectlively. The peak and mean concentrations of the protal vein were 13. 3 and 6. 8 times than the femoral vein's, Intraperito neal chemotherapy of carboplatin can maintain a stable and persistent high level in the peritoneal cavity, portal vein as well as liver, Action of killing cancer cells increased greatly. Toxicant of all body was decreased due to low level of drug in the systemic circulation. These pharmacokinetic properties of carboplatin are of advantage in preventing and treating tumor recurrence in the peritoneal cavity and hepatic metastases after the operation of gastrointestinal tumor.
出处
《河北医学》
CAS
1996年第6期556-558,共3页
Hebei Medicine
关键词
碳铂
药代动力学
腹腔内化疗
Carboplatin
Pharmacokineic
Intraperitoneal Chemotherapy
