摘要
目的观察抑郁症患者血清S100B浓度的变化，并分析其与抑郁症患者的首发年龄、发作次数、临床症状严重程度之间的相关性。方法研究对象为抑郁症患者79例，以及年龄和性别相匹配的健康体检者79例。利用酶联免疫吸附法检测血清S100B的浓度，采血同时利用17项汉密尔顿抑郁量表（HAMD-17）评定临床症状的严重程度。结果抑郁症患者血清S100B浓度（O．15±0．03）μg／L高于正常组（O．11±0．03）μg／L，差异具有统计学意义（P〈0．01）；抑郁症患者的发作次数、症状的严重程度与血清S100B有相关性。结论血清S100B可能作为抑郁症诊断的生化指标，并且在抑郁症疾病的发展中具有一定的作用。
Objective To investigate the changes the concentrations of serum S100B in patients with depression and analyze its association with clinical features of depression such as the age at onset, the times of attacks, the severity of clinical symptoms and so on. Methods Serum S100B levels were measured using an immunoluminometric assay （ELISA） and the severity of clinical symptoms were assess using the Hamilton Depression Rating Scale--17 （HAMD--17） from 79 patients with depression and 79 age and gender matched healthy volunteers. Results The serum SI00B levels were significantly higher in depression group than in control group. The concentrations of serum S100B were related to the times of attacks and the severity of clinical symptoms,but not related to age at onset. Conclusions Serum S100B could be used as a biochemical marker for diagnosis of depression. It may be associated with the times of attacks and the severity of clinical symptoms in depression patients.
出处
《神经疾病与精神卫生》
2012年第4期379-381,共3页
Journal of Neuroscience and Mental Health
