摘要
目的:探讨血清一氧化氮(NO)水平与抑郁症之间的关系。方法:治疗前和治疗第2、4、8周分别检测抑郁症患者血清NO含量,并与对照组比较。结果:治疗前,抑郁症组血清NO水平与对照组相比,差异具有显著性(P<0.01)。两组的血清NO水平与年龄、性别无明显相关。抑郁症组的血清NO水平与发病年龄、严重程度、病程、情感障碍家族史以及有无自杀行为均无明显关系。治疗第2、4、8周抑郁症患者血清NO水平逐渐降低致对照组水平,与治疗前相比差异有显著性(P<0.01)。结论:NO可能在抑郁症的发病机制中起一定作用。
Objective：To explore the relationship between the level of the serum nitric oxide （NO） and the features of depressive disorder. Method ： The serum NO level of the depressive patients were measured and compared with the normal group before and after 2,4,8 weeks treatment. Results：Before treatment, the depressive group had significant difference compared with normal group in the serum NO level （P 〈 0. 01 ）. No significant correlation were found among the level of the serum NO and age or gender between the two groups. There was no significant relationship between the level of the serum NO and age of onset, severity of the disease, duration, family history of mood disorders, suicidal behavaior. The level of the serum NO decreased gradually after 2,4,8 weeks treatment, and was significantly different compared with baseline （P 〈 0.01 ） Conclusion： NO might be involved in the pathogenesis of the depression.
出处
《临床精神医学杂志》
2008年第5期317-319,共3页
Journal of Clinical Psychiatry
关键词
抑郁症
一氧化氮
depressive disorder
nitric oxide
