摘要
目的 评价肝细胞癌肿瘤坏死与经动脉化疗栓塞 (TACE)方法的关系。材料与方法 观察 117例手术切除的肝细胞癌肿块坏死和增长率 ,其中单纯手术 5 8例 ,4种TACE后Ⅱ期手术切除 5 9例。结果 肝细胞癌TACE后坏死较自发坏死严重、范围广(P <0 .0 1) ,坏死程度和肿块体积变化与TACE方法密切相关 (多材料联合栓塞较单材料栓塞、单纯化疗改变明显 ,P <0 .0 1) ,但与TACE和手术切除间期无显著相关 (P >0 .0 5 ) ,坏死程度和体积变化显著相关 (P <0 .0 1) ,多次TACE较单次易引起肿瘤坏死 ,但无统计学意义。本组完全坏死率 2 0 .3 % ,仅见于多材料联合栓塞组。结论 多次、多材料联合栓塞TACE较单次、单材料栓塞、单纯化疗更易引起肝细胞癌坏死及肿块体积缩小 ,有效的TACE早期 ( <1个月 )即可引起肿块广泛坏死。
Objective To study the relationship between tumor necrosis and transcatheter arterial chemoembolization (TACE) methods for hepatocellular carcinoma (HCC).Materials and Methods Tumor necrosis and volume were examined in 117 surgical specimens, including 58 cases treated with surgery alone and 59 cases treated with 4 kinds of TACE before surgery.Results Necrosis due to TACE was more severe and extensive than that seen in spontaneous cases (P<0.01). Significant difference in necrosis extent and mass volume existed between multiple material embolization and single material embolization or pure chemotherapy (P<0.01), while no relationship was found between these changes and the TACE surgery intervals (P>0.05). Necrosis severity was significantly related to the changes of the mass volume (P<0.01). Repeated TACE was more apt to cause tumor necrosis than single TACE, though no statistic significance was seen (P>0.05). In this study, total necrosis was found in 20.3% cases, only seen in the patients treated with multiple material embolization.Conclusion Repeated, multiple material embolization TACE can more easily cause necrosis and shrinkage of HCC than single treatment with one material or single chemotherapy can. An effective TACE will cause massive necrosis of the tumor within one month.
出处
《临床放射学杂志》
CSCD
北大核心
2000年第8期512-515,共4页
Journal of Clinical Radiology
关键词
肝细胞癌
经动脉化学栓塞
病理学
肿瘤坏死
Carcinoma,hepatocellular Chemoembolization,therapeutic Pathology
