摘要
目的 通过比较一氧化氮 (NO)供体硝酸甘油及硫酸镁对妊高征患者血中 NO及内皮素 (ET)的影响 ,为硝酸甘油治疗妊高征提供理论依据 .方法 于用药前、后 30 min分别抽取患者肘静脉血 .以活化镉还原剂与 Griess反应结合法测定血清中 NO的代谢产物 ;放射免疫法测定血浆中 ET的含量 .结果 妊高征患者使用硝酸甘油后 ,血中 NO代谢产物明显增多 (P<0 .0 5 ) ,ET明显下降 (P<0 .0 5 ) ,ET与 NO代谢产物的比值明显下降 (P<0 .0 5 ) .结论 硝酸甘油不仅可增加血中 NO含量 ,而且可减少血中 ET含量 ,纠正 ET/NO的比例失衡 。
AIM To compare the effect of nitroglycerin with that of magnesium sulphate on the plasma level of nitric oxide (NO) and serum level of endothelin (ET) in patients with pregnancy-induced hypertension, and to provide theoretical bases for the use of nitroglycerin and magnesium sulphate in patients with pregnancy-induced hypertension. METHODS Plasma NO endoproducts were measured with the Griess reaction and serum ET was measured by redioimmunoassay before and after the treatment with nitrioglycerin. RESULTS After nitroglycerin administration, NO endoproducts level in-creased significantly ( P <0.05) and ET level decreased significantly ( P <0.05). The ratio of ET to NO 2 -/NO 3 - increased significantly ( P <0.05). CONCLUSION Nitroglycerin can not only increase NO level but also decrease serum ET; the imbalance between ET and NO can be corrected as a result. It could be used in the treatment of PIH.
出处
《第四军医大学学报》
2000年第7期897-899,共3页
Journal of the Fourth Military Medical University
