摘要
目的 :初步探讨 、 期乳腺癌切除范围及 VEGF、nm2 3- H1在乳腺癌及癌旁组织中的表达。方法 :应用免疫组化方法对 32例乳腺癌及癌旁组织中 VEGF和 nm 2 3- H1表达进行测定并同时测定乳腺癌组织的浸润距离。结果 :32例乳腺癌肿瘤组织 VEGF的过表达率为 2 0 / 32 (6 2 .5 % ) ,nm2 3- H1的低表达率为 14/ 32 (43.8% ) ,而在距肿瘤 2 cm的癌旁组织中 ,6例癌变组织 VEGF的过表达率为 3/ 6 ,nm 2 3- H1的低表达率为 2 / 6 ,5例不典型增生组织及 2 1例正常组织中 VEGF及 nm2 3- H1均为正常表达。31例肿瘤浸润在 2 .5 cm以内。结论 :乳腺癌浸润绝大多数局限在 2 .5 cm之内 ,VEGF过表达或 nm 2 3- H1低表达者仅在肿瘤组织中 ,不典型增生及正常组织均不表达。
Objective: To peliminarily study VEGF over-expression and nm23-H1 low-expression and the operation range of breast cancer of stage Ⅰ and Ⅱ . Method:To determine the operation range of breast cancer of stage Ⅰ and Ⅱ by making section and the expression level of VEGF and nm23-H1 of 32 patients in breast cancer and surrounding tissues by immunohistochemistry .Results:VEGF over-expression was 20/32(62.5%) and nm23-H1 low-expression was 14/32(43.8%) in breast cancer tissus. in surrounding tissues ,the over-expression of VEGF was 3/6 and the low-expression of nm23-H1 was 2/6 which was only found in breast cancer tissues .Conclusion: Most of infiltration distance of breast cancer of stage Ⅰ and Ⅱ are within 2.5cm,VEGF over-expression and nm23-H1 low-expression are only found in cancer tissues . [
出处
《南通医学院学报》
2000年第3期239-240,共2页
ACTA Academiae Medicinae Nantong
