摘要
为探讨 CCR5、CCR2和 SDF1等位基因的突变和多态性特点 ,评估不同人群对 HIV- 1感染的遗传易感性 ,作者收集近年来国际上报道的人类免疫缺陷病毒 (human immunodeficiency virus- 1,HIV- 1)感染基因相关文献资料 ,其中包括作者检测的中国人基因组的 CCR5、CCR2和 SDF1基因多态性的检测结果。通过对比分析 ,结果显示世界上不同人群的 HIV- 1相关基因的突变和多态性有一定的差异 ;并与艾滋病(acquired immunodeficiency syndrome,AIDS)发病过程之间有明确的相关性。与美国白人相比 ,中国人群对M- tropic的 HIV- 1株易感性较大 ,这一结果为我国对 AIDS的预防和未来的基因治疗提供了初步依据。
To investigate the genetic susceptibility of different ethnic populations to human immunodeficiency virus 1(HIV 1) infection by comparing the characteristics of gene mutation frequency and polymorphism of CCR5, CCR2 and SDF 1 alleles among different nationalities in the world.The recently reported data on AIDS progression in patients, and on gene mutation and polymorphism of CCR5, CCR2b and SDF 1 genes were collected. The data also included the HIV 1 associated genes polymorphisms of the Chinese individuals detected by the present authors. There was a significant link between the gene mutation, polymorphism of HIV 1 associated genes, genetic susceptibilities and the AIDS progression in patients, although the differences of HIV 1 associated gene mutation, polymorphisms existed among different ethnic populations in the world.The Chinese individuals are more likely to be infected by the M tropic HIV 1 strain than the American Caucasian. The Chinese individuals have very low gene mutation of CCR5△32, which would be helpful for the prevention and gene therapy against the HIV 1 infection.
出处
《中华医学遗传学杂志》
EI
CAS
CSCD
北大核心
2000年第4期285-287,共3页
Chinese Journal of Medical Genetics
基金
国家自然科学基金!(39770 683)
关键词
遗传易感性
艾滋病
基因多态性
HIV
基因治疗
human immunodeficiency virus 1
genetic susceptibility
acquired immunodeficiency syndrome
polymorphism
