摘要
[目的]考察骨碎补外用对环磷酰胺致C57BL/6小鼠斑秃模型的影响。[方法]采用环磷酰胺腹腔注射建立C57BL/6小鼠斑秃模型,观察骨碎补外用对小鼠毛囊组织学变化和血清细胞间黏附蛋白(ICAM-1)、内皮细胞-白细胞黏附分子-1(ELAM-1)水平的影响。[结果]骨碎补外用能使实验性斑秃模型小鼠血清ICAM-1和ELAM-1水平降低,毛囊数增多(P<0.05或P<0.01)。[结论]骨碎补外用能够抑制毛囊进入退行期,对斑秃模型小鼠具有治疗作用。
[Objective] To investigate the effects of Drynaria fortunei on alopecia areata induced by cyclophosphamide in C57BL/6 mice. [Methods] Severe alopecia was induced by cyclophosphamide in these mice. The hair growth and histological changes were observed in the back skin of them. The levels of ICAM-1 and ELAM-1 in the serum were determined by ELISA. [Results] The levels of ICAM-1 and ELAM- 1 in herbal group were lower than that in the control group. The nutrition of hair follicles was also improved. [Conclusions] The extract from Drynaria fortunei has a promoting effect on the hair growth by its external application.
出处
《天津中医药》
CAS
2012年第4期375-377,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
国家科技支撑计划项目(2008BA153B09)
关键词
骨碎补
外用
环磷酰胺
斑秃
Drynaria fortunei
external application
cyclophosphamide
alopecia areata
