摘要
给予34例高脂血症患者服用中药调脂汤,测定其服药前后血高密度脂蛋白胆固醇(HDL-C)及其亚组分 HDL_2-C、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白 A-I(apoA-I)、载脂蛋白 B(aPoB)水平的变化。并用烟酸肌醇酯加脉通口服进行对照。服药4周后观察组患者血清 LDL-C、apoB 水平较治疗前显著降低(P 分别<0.01,0.001);HDL-C、HDL_2-C、apoA-I 水平显著升高(P 均<0.001)。在降低 LDL-C、apoB,升高 HDL-C 水平方面,调脂汤的作用明显优于对照组(P 均<0.05)。
In this research,68 patients suffering from hyperlipemia were divided into observation group taking Tiao-Zhi-Tang(TZT) and control group taking inositol and Mai Tong(脉通)at random and matched-pair,and the serum levels of HDL-c,HDL2-c,LDL-c,Apo A-Ⅰ and Apo B were measured respectively by the methods of polyethylene glycol precipitation separation and single radial im- munodiffusion.The results showed that there were significant difference in the levels of lipoprotein, apolipoprotein between the patient groups and the healthy group before taking medicines.After taking medicines for four weeks,the serum levels of total cholesterol,triglyceride(TG),LDL-c and Apo B were lowered and the serum levels of HDL-c,HDL2-c and Apo A-Ⅰ were elevated in the observation group.The serum level of TG was lowered and the serum levels of HDL2-c,Apo A-1 were elevated in the control group.The effects of TZT.with the serum levels of LDL-c and Apo B being lowered and the serum level of HDL-c being elevated,were more beneficial than inositol and Mai Tong.These results suggested that TZT had (?)d effect on regulating the lipoprotein metabolism.
