期刊文献+

单纯化疗与放化疗联合治疗局部晚期非小细胞肺癌的疗效、毒性反应及对生存的影响观察

暂未订购
导出
摘要 目的观察单纯化疗与放化疗联合治疗局部晚期非小细胞肺癌的疗效、毒性反应及对生存的影响。方法选择2007年5月至2008年6月45例不能手术的局部晚期非小细胞肺癌患者,分为单纯化疗组(A组)22例、放化疗联合组(B组)23例。观察两组近期与晚期治疗效果。结果 A组PR8例,临床控制率36.36%,B组CR2例,PR13例,临床控制率65.22%,两组短期疗效比较差异具有显著性,有统计学意义P<0.05。A组1、2、3年生存率分别是40.91%、22.73%、0%;B组1、2、3年生存率分别是65.22%、39.13%、13.04%,两组差异有显著性(P<0.05)。两组主要毒副反应为骨髓抑制和消化道反应。无Ⅳ度白细胞减少病例,两组不良反应差异无显著性(P>0.05)。结论放化疗联合治疗局部晚期非小细胞肺癌的疗效优于单纯化疗,可提高1、2、3年生存率,且毒副反可耐受。
出处 《中国医药指南》 2012年第21期144-145,共2页 Guide of China Medicine
  • 相关文献

参考文献4

二级参考文献17

  • 1傅小龙,将国梁,王丽娟,钱浩,傅深,叶明,赵森.局部控制在非小细胞肺癌非手术治疗中意义的探讨[J].上海医学,1996,19(10):559-562. 被引量:20
  • 2Mountain C. Revisions in the international system for staging lung cancer. Chest,1997 111:1710-1717.
  • 3Komaki R, Scott CB, Byhardt R, et al. Failure patterns by prognostic group determined by recursive partitioning analysis ( RPA ) of 1547 patients on four radiation therapy oncology group (RTOG)studies in inoperable nonsmall-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 1998 42,263-267.
  • 4Werner-Wasik M, Scott C, Cox JD, et al. Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC) : identification of five groups with different survival. Int J Radiat Ontol Biol Phys,2000 48 : 1475-1482.
  • 5Schild SE, Stella PJ, Geyer SM, et al. The outcome of combined-modality therapy for stage Ⅲ non-small-cell lung cancer in the elderly. J Clin Oncol, 2003 21:3201-3206.
  • 6Etiz D, Marks LB, Zhou SM, et al. Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys, 2002 53:835-846.
  • 7MacRae R, Shyr Y, Johnson D, et al. Declining hemoglobin during chemoradiotherapy for locally advanced non-small cell lung cancer is significant. Radiother Oncol, 2002 64:37-40.
  • 8Dillman RO, Hemdon J, Seagren SL, et al. Improved survival in stage Ⅲ non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial. J Natl Cancer Inst,1996 88 : 1210-1215.
  • 9Sause WT, Scott C, Taylor S, et al. Radiation Therapy Ontology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group(ECOG) 4588 : preliminary results of a phase Ⅲ trial in regionally advanced, unresectable non-small-cell lung cancer. J Natl Cancer Inst, 1996 87:198-205.
  • 10Furase K, Fukuoka M, Kawahara M, et al. Phase Ⅲ study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage Ⅲ non-small-cell lung cancer. J Clin Oncol, 1999 17:2692-2699.

共引文献80

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部