摘要
目的:探讨姜黄素对支气管哮喘大鼠气道重塑及核因子-κB(NF-κB)的影响。方法:将Wistar大鼠随机分为对照组、哮喘组、姜黄素组,各10只;采用卵蛋白(OVA)致敏复制大鼠哮喘模型。观察3组大鼠气道炎症、气道壁厚度、胶原沉积及NF-κB和转化生长因子(TGF-β1)表达情况。结果:哮喘组大鼠炎性细胞浸润、胶原沉积、气道壁厚度、NF-κB、TGF-β1表达与对照组比较有显著性差异(P<0.01),而姜黄素组较哮喘组明显减轻(P<0.01);NF-κB与TGF-β1表达、气道炎症、气道壁厚度、胶原沉积变化成正相关(P<0.01)。结论:姜黄素可抑制哮喘大鼠NF-κB活性以干预其气道重塑。
Objective： To investigate the influence of cureumin on airway remodeling and nuclear factor kappa-B（NF-kB） in rats with asthmas. Methods： Wistar rats were randomly divided into three groups： control group, asthma group and curcumin group, lO rats in each group. Asthma model was duplicated by injecting ovalbumin （ OVA ）. The airway inflammation, thickness, collagen deposit, NF-kB and transformation growth factor betal （TGF-β1） were observed. Results： There were significant differences in airway inflammation, thickness, collagen deposit, NF-kB and TGF-β1 expressions between control group and asthma group, and between asthma group and eurcumin group（P 〈 0.01 ） ; NF-KB expression was positively correlated with TGF-β1 expression, airway inflammation, airway thickness and collagen deposition（P 〈 0.01 ）. Conclusion： Cureumin can down-regulate NF-KB expression to suppress airway remodeling in asthma tats.
出处
《上海中医药大学学报》
CAS
2012年第4期92-94,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
甘肃省中医药科研基金资助项目(05-GZK-20)
