摘要
目的观察平喘合剂对哮喘模型大鼠血浆及肺泡灌洗液(BALF)中IL-2、IL-4含量的影响,探讨平喘合剂治疗哮喘的作用机理。方法选择雄性Wistar大鼠随机分为正常组(不造模)、模型组(造模后予生理盐水)、博利康尼组(造模后予博利康尼)、痰喘丸组(造模后予咳嗽痰喘丸)、平喘合剂组(造模后予平喘合剂),比较组间血浆及BALF中IL-2、IL-4的含量。结果平喘合剂组血浆及BALF中IL-4与血浆中IL-2均低于各造模组,而与正常组接近,其BALF中IL-2与各组均相近。结论平喘合剂可明显改善哮喘模型大鼠血浆中IL-2、IL-4含量的异常升高,效果优于博利康尼和痰喘丸。
To investigate the effect of Pingchuan Mixture (平喘合剂) on asthma by observing the levels of IL-2 and IL-4 in plasma and bronchoalveolar lavage fluid (BALF) of asthmatic rats.Methods:Male Wistar rats were selected and randomly divided into 5 groups:the normal group,the model group(NS group),the bricanyl group,the Tanchuan Pill(痰喘丸) group and the Pingchuan Mixture(平喘合剂) group.Then measured and contrasted the levels of IL-2 and IL-4 in plasma and BALF of the rats in each group.Results:The levels of IL-4 in plasma and BALF of Pingchuan Mixtrue group is lower than those in the Model group,Bricanyl group and Tanchuan Pill group,while the levels have no significant difference with those in the normal group.The level of IL-2 in each group were approximately equal.Conclusion:Pingchuan Mixture can significantly improve the abnormal elevation of IL-4 and IL-2 of asthmatic rats' blood plasman,and its effect is better than bricanyl and Tanchuan Pill.
出处
《中国中医急症》
2004年第11期758-759,共2页
Journal of Emergency in Traditional Chinese Medicine
