摘要
目的探讨无症状高尿酸血症对人体微炎症状态的影响。方法选择我院体检人群中无症状高尿酸血症及同期的血尿酸正常者各40例，检测两组对象的微炎症指标：C-反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的水平。无症状高尿酸血症者予以低嘌呤饮食或低嘌呤饮食＋别嘌呤醇治疗2个月后再次检测其微炎症指标，比较治疗前后变化情况。结果两组对象的肾功能均正常且无明显差异，高尿酸血症组治疗前后肾功能无明显变化。高尿酸血症组CRP、IL-6、TNF-α明显高于血尿酸正常组。经低嘌呤饮食及低嘌呤饮食＋别嘌呤醇治疗2个月后，高尿酸血症组的血尿酸水平明显下降（P〈0．05），且CRP、IL-6、TNF-α的水平均较治疗前明显降低（P〈0．05）。结论无症状高尿酸血症与微炎症状态密切相关。
Objective To explore the relationship between asymptomatic hyperuricemia and the state of micro inflammation in human body. Methods 80 cases were chosen as the research objects and those were divided into two groups：normouricemia group and hyperuricemia group. The markers of micro inflammation C-reactive protein （ CRP）, interleukin（IL） -6, tumor necrosis factor（TNF） -α were detected. The objects of hyperuricemia group should be detected those again after administrating a low purine diet and using allopurinol for 2 months. The level of markers of micro inflammation were compared between the two groups before and after the intervention of objects with hyperuricemia. Results The objects of both groups had normal renal function and there were no significant difference in renal function either between two groups or between before and after treatment in objects of asymptomatic hyperuricemia. The plasma concentrations of CRP, IL-6,TNF-α in persons of the hyperuricemia group were significantly higher than it of the normouricemia group（ P 〈 0.05 ）. Though it would be obviously improved by administrating a low purine diet and using allopurinol（P 〈 0.05 ）. Conclusion It has been demonstrated that hyperuricemia is associated with micro inflammation closely.
出处
《临床内科杂志》
CAS
2012年第7期460-462,共3页
Journal of Clinical Internal Medicine
关键词
高尿酸血症
无症状
微炎症
Hyperuricemia,asymptomatic
Micro inflammation
