摘要
目的:研究消旋棉酚晶形结构。方法:采用红外光谱(IR)、差示扫描量热法(DSC)、测定溶解度和粉末X射线衍射法(XRD)来研究消旋棉酚晶态结构。结果:消旋棉酚[(±)G]、左旋棉酚[(-)G]和右旋棉酚[(+)G]的红外谱图基本相同;DSC图谱及热特征数据不一致;在消旋棉酚的饱和溶液中加入光学活性棉酚,光学活性棉酚可以继续溶解,并且有旋光产生;(±)G与(-)G及(+)G的XRD图完全不同。结论:消旋棉酚晶体属于外消旋化合物。
Objective：To investigate the crystal structure of racemic gossypol.Methods：The infrared spectroscopy（IR）,differential scanning calorimetery（DSC）,determination of solubility and powder X-ray diffractometry were used to study the crystal structure of racemic gossypol.Results：Racemic gossypol,l-gossypol and d-gossypol had basically the same infrared absorption spectra,but they had different DSC curves and thermal characteristics data.Also when added into a saturated solution of racemic gossypol,the optically active gossypol was dissolved further and optical rotation was created.And the XRD curve of（±） G was completely different from（-） G and from（＋） G.Conclusion：Racemic gossypol is a racemic compound.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2012年第8期1370-1373,共4页
Chinese Journal of Pharmaceutical Analysis
基金
兵团博士基金项目(2009JC14)
国家教育部重点课题(205815)
关键词
消旋棉酚晶态结构
光学活性棉酚
差示扫描量热法
溶解度测定
红外光谱法
高效液相色谱
粉末X射线衍射法
crystal structure of racemic gossypol
optically active gossypol
differential scanning calorimetery
solubility test
infrared spectrometry
HPLC
powder X-ray diffractometry
