摘要
目的评估雷氏强力天麻杜仲胶囊联合甲钴胺治疗糖尿病周围神经病变的疗效,探讨强力天麻杜仲胶囊治疗糖尿病周围神经病变的有效性。方法糖尿病合并周围神经病变患者140例,分为强力天麻杜仲联合甲钴胺治疗组(A组)35例、卡马西平联合甲钴胺治疗组(B组)35例、单用强力天麻杜仲组(C组)和单用甲钴胺治疗组(D组)各35例。用药8周后比较4组患者临床症状缓解率、用药前后肌电图及下肢动脉超声改变、检测患者血肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及血流变指标。结果与D组比较,A、B组周围神经症状缓解率提高。A组感觉神经传导波幅改善更为明显,胫神经H反射潜伏期缩短。下肢动脉超声显示A组和C组患者用药后下肢动脉多普勒流速曲线参数增加。A组和C组用药后血IL-6、TNF-α水平显著降低、血流变指标改善。结论强力天麻杜仲胶囊联合甲钴胺能够明显缓解糖尿病周围神经病变患者临床症状、改善下肢动脉血流和神经传导速度及胫神经H反射、减轻机体炎症反应。
AIM To evaluate the effects of the combination of Gastrodia Elatacortex Capsules and Mecobalamin Injection on diabetic peripheral neuropathy （DPN）. METHODS Total 140 patients diagnosed as DPN, were divided into four groups. The efficacy of treatment, electromyography, artery ultrasound of lower limbs, and the serum levels of TNF-a and IL-6, as well as blood viscosity were examined before and after 8-week treatment. RESULTS Patients who were given Gastrodia Elatacortex Capsules with Mecobalamin Injection represented higher efficacy, faster nerve conductive velocity, and more sensitive of H reflex latency of tibial nerves. Patients who were given Gastrodia Elatacortex Capsules, with or without Mecobalamin, demonstrated elevated blood flow velocity in their arteries of lower limbs. Furthermore, they displayed declined serum TNF-a and IL-6 levels, and blood viscosity. CONCLUSIONS Gastrodia Elatacortex Capsules with Mecobalamin Injection has an effect on DPN patients. The impaired nerve conductive velocity, H reflex, and the artery blood flow velocity of lower limbs could be improved by Gastrodia Elatacortex Capsules, which implies that Gastrodia Elatacortex Capsules might inhibit the activated inflammation in patients with diabetic peripheral neuropathy.
出处
《中成药》
CAS
CSCD
北大核心
2012年第8期1451-1455,共5页
Chinese Traditional Patent Medicine
关键词
糖尿病周围神经病变
强力天麻杜仲胶囊
甲钴胺
肌电图
diabetic peripheral neuropathy （DPN）
Gastrodia Elatacortex Capsules
Mecobalamin
electromyography
