摘要
目的:消除异丙酚诱导时心血管抑制作用,探讨一种较为安全、合理的麻醉诱剂药物配伍。方法:随机选择20例ASAI~Ⅱ级、非心脏手术的全麻患者。采用氯胺酮(1mg/kg)、异丙酚(1.5~2.0mg/kg)、芬太尼(4μg/kg)、琥珀胆碱(2.0mg/kg)诱导,行气管插管,观察其心血管反应。结果:麻醉诱导时、气管插管即刻、气管插管后1、2、3min,收缩压(SBP)、舒张压(DBP)、心率(HR)、平均动脉压(MAP)均无明显变化(P<0.05)。结论:将小剂量的氯胺酮和芬太尼与异丙酚联合应用,既能有效地抑制气管插管时的心血管副反应,又能减轻异丙酚单独用于诱导时心血管抑制作用。
Objective:To eliminate cardiovascular inhibition of propofol induction,searching for a safer and more reasonable drug combination of intravenous induction.Methods:Twenty patients(ASA I~Ⅱ)were chosen randomly.Patients undergoing cardiac surgery were exclude.Medication of induction:Ketamine 1 mg/kg,Propofol 1.5~2.0 mg/kg,Fentanyl 4μg/kg,Scoline 2.0 mg/kg.During intubation,cardiovascular effects were observed.Results:The changes of SBP,DBP,HR,MAP at five period(Induction,intubation,the 1th,2th,3th minute after intubation)were nosignificant.Conclusion:Drug combination of little dose of Ketamine,Propofol,and Fentanyl can not only inhibit cardiovascular side effect significantly during intubation,but also decrease cardiovascular inhibition of Propofol.
作者
夏芳
詹丽英
邹汉东
黄海波
曹经山
Xia Fang;Zhan Liying;Zou Handong(Department of Anesthesiology,First Affiliated Hospical,Hubei Medical University,Wuhan 430060,China)
