摘要
目的:观察替普瑞酮与奥美拉唑联合应用,与奥美拉唑或者替普瑞酮长期单独应用,预防患者NSAIDs(非甾体类抗炎药)所致溃疡以及出血的治疗效果和安全性。方法:对我单位自2004年11月～2011年11月以来治疗的134例溃疡出血患者临床资料进行回顾性分析,全部患者均长期应用NSAIDs治疗,入院经胃镜下止血后,将其随机分为A、B、C 3组,对3组患者在0～8周以及9～40周后,再出血的发生率与不良反应的发生率进行观察对比。结果:经治疗8周后3组患者再出血的发生率分别是:A组8.0%,B组36.8%,C组13.0%,3组具有明显差异(P<0.05);A组再出血的发生率较B组具有明显差异(P<0.05);经治疗40周后3组患者再出血的发生率分别是,A组12.0%,B组10.5%,C组17.4%,3组差异不具有统计学意义(P>0.05)。结论:对患者短期应用奥美拉唑联合替普瑞酮治疗后,再予以替普瑞酮维持治疗的方法,对预防及治疗由NSAIDs导致患者溃疡以及出血方面,能够达到同PPI(质子泵抑制剂)相同的治疗效果,同时还可避免由于长期应用PPI所引起的临床并发症,应予临床推广。
Objective：Teprenone observed with omeprazole in combination with omeprazole or Teprenone long alone, to prevent patients with NSAIDs （nonsteroidal anti - inflammatory drugs） due to ulcers and bleeding treatment efficacy and safety. Methods： Our hospital from November 2004 to November 2011 has been treated in our department of 134 cases of ulcer bleeding in patients with clinical data were retrospectively analyzed all pa- tients treated long term use of NSAIDs, bleeding after admission by endoscopy, to ABC randomly divided into three groups, 0-- 8 of 3 patients in the weeks and 9 -- 40 weeks, the incidence of rebleeding and the incidence of adverse reactions were observed contrast. Results： The three groups after 8 weeks of treatment the incidence of rebleeding in patients are： A group of 8.0 %, B group 36.8 %, C group 13.0 %, three groups with differences（P〈 0.05）; A group compared with the incidence of rebleeding group B with a significant significant difference （P 〈 0.05） ; 40 weeks after treatment and then three groups of patients were the incidence of bleeding, A group of 12.0 %, B group 10.5 %, C group 17.4 %, three groups do not have significant difference （P 〉0.05）. Conclusion-Omeprazole in patients with short- term application of Teprenone, and then be Teprenone maintenance treatment methods, prevention and treatment by NSAIDs cause ulcers and bleeding in patients, can be achieved with PPI （proton pump inhibitors） the same therapeutic effect, but can also avoid the application of PPI caused by long- term clinical complications and should be popularized.
出处
《内蒙古医学杂志》
2012年第5期542-544,共3页
Inner Mongolia Medical Journal
