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阿托伐他汀的临床应用进展 被引量:20

Advance of Clinical Application for Atorvastatin
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摘要 阿托伐他汀是最有效而安全的他汀类药,明显降低心血管风险。即使介入术后更强调应服用他汀药,不仅能改善心肌缺血,更能预防心肌梗死,改善生存率和预后。该药除调脂作用外,可有效降低高血压、糖尿病、冠心病、动脉粥样硬化、心力衰竭、脑卒中、骨折、急性冠状动脉综合征的发病率和病死率。指南强调对急性冠状动脉综合征患者应尽早应用,长期坚持强化他汀药治疗,改善冠状动脉斑块生物学特征,逆转不稳定斑块,改善患者近、远期预后。 Atorvastatin is the most effective and safe statin, significantly reduce cardiovascular risk, even more emphasis should be in- volved in service after the statin drugs, not only can improve myocardial ischemia, but also can prevent myocardial infarction, improved sur- vival and prognosis. In addition to lipid drug,it can effectively reduce the incidence and mortality of hypertension, diabetes, coronary heart disease, atherosclerosis, heart failure, ischemic stroke, removed bone, and acute coronary syndrome. Guidelines emphasize the application for patients with acute coronary syndrome as soon as possible and insistent treatment of intensive statin drugs, the improving of biological characteristics of coronary plaques, reversing of unstable plaques, and the improving of short- and long-term prognosis in patients.
出处 《心血管病学进展》 CAS 2012年第4期553-557,共5页 Advances in Cardiovascular Diseases
关键词 阿托伐他汀 不稳定斑块 心血管风险 atorvastatin unstable plaques cardiovascular risk
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参考文献33

  • 1徐大立,杨承建,陶以嘉,等.阿托伐他汀在心血管保护作用[J].中华实用l医学研究杂志,2006,7:1-2.
  • 2徐大立,刘颖,范永华,王燎,陶以嘉.急性心肌梗死的研究进展[J].心血管病学进展,2005,26(B08):86-92. 被引量:9
  • 3Schwartz GG, Olsson AG, Ezekowitz MD,et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial [J]. JAMA,2001,285(13) :1711-1718.
  • 4Espinola-Klein C, Rupprecht HJ, Erbel R, et al. Ten-year outcome after coro- nary angioplasty in patients with sing/e-vessel coronary artery disease and com- parison with the results of the Coronary Artery Surgery Study (CASS) [J]. Am J Cardiol, 2000,85:321-326.
  • 5Ardastmi E, Mordini P, Beno BD, et al. New insights into pathophysiology of AMI : from plaque biology to clinical setting [ J ]. Am Heart J, 1999,138 : 556- 560.
  • 6徐大立,李旭东,陶以嘉,等.高血压病研究新进展[J].中华实用医学研究杂志,2006,2:2-13.
  • 7徐大立,钱中良,陶以嘉,等急性冠脉综合怔研究新进展[J].中华实用医学研究杂志,2006,17:36.
  • 8Goldstein JL, Brown MS. Regulation of the meralonate pathway [ J ]. Nature, 1999,343:425-430.
  • 9Bernot D, Benoliel AM, Peiretti F, et al. Effect of atorvastatin on adhesive phenotype of human endothelial cells activated by tumor necrosis factor alpha [ J]. J Cardiovasc Pharmacol, 2003,41 (2) :316-324.
  • 10Wada H, Mori Y, Kaneko T, et al. Elevated plasma levels of vascular endo- thelial ceil markers in patients with hypercholesterolemia [J]. Am J Hemaml, 1993,44 : 112-116.

二级参考文献16

  • 1张涛,李自成.冠心病易损斑块的研究进展[J].临床心血管病杂志,2004,20(8):509-512. 被引量:18
  • 2徐大立,陶以嘉,范永华,刘颖,沈德怀.心力衰竭研究进展[J].心血管病学进展,2004,25(B12):114-118. 被引量:9
  • 3Wikstrand J, Bergland G, H edblad B ,et al. Antiatherosclerotic effects of β-blockers[ J]. Am J Cardiol,2003,91 (12) :25-29.
  • 4Hedblad B,Wikstrand J,Janzon L,et al. Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media Ihickness:Main results from the β-Blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS) [ J ]. Circulation ,2001 , 103 ( 13 ) : 1721-1726.
  • 5Gottlieb SS, Mccarter RJ,Vogel RA. Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction [ J ]. N Engl J Med,1998,339 ( 8 ) :489-497.
  • 6The Acute Infarction Ramipril Efficacy (AIRE) study. Investigator effect of ramipril on mortality and morbidity of survivors of acute mycardial infarction with clinical evidence of heart failture[ J ]. Lancet, 1993,342:821.
  • 7Goldstein JL, Brown MS. Regulation of the meralonate pathway [ J ] , Nalure,1999,343:425 -430.
  • 8Antman EM. Decision making with cardiac troponin tests [ J ]. N Engl J Med,2002,346(26) :2079-2082.
  • 9黄峻世.现代循证心脏病学[M].南京:江苏科学技术出版社,2002.283-350.
  • 10Herlitz J, Emanuelsson H, Swedberg K, et al, Goteborg Metoprolol Trial: Enzgmeestimated infarct size[ J ]. Am J Cardiol, 1984,53 ( 13 ) : 15D-21D.

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