摘要
纤维化是肝脏对于肝实质损伤的修复反应,其形成过程包括致病因素、效应细胞、信号及进行信号调节的分子。纤维化的效应细胞是肌成纤维细胞,具有快速增殖能力,增加合成细胞外基质,表达基质金属蛋白酶及其抑制物。肝纤维化在一定的阶段经过干预,其进程可逆,但在发病机制与治疗方面仍有许多问题尚未解决。
Fibrogenesis is a typical reaction of the liver to injury, the process of which has a cause, effector cells, signals and signal regulatory molecules. The effector cells of fibrogenesis are myofibroblasts, which have the ability of rapid proliferation, increased synthesis of ECM, expression of matrix metalloproteinases and their inhibitors. In a given stage, fibrogenesis is reversible under certain intervention, though there are still iota of problems tobe resolved inpathological mechanism and treatment.
出处
《医学综述》
2012年第14期2155-2158,共4页
Medical Recapitulate
基金
国家自然科学基金(30670960)
