摘要
目的 :研究尿道压力分布图 (UPP)对良性前列腺增生 (BPH)患者α肾上腺素能受体阻滞剂治疗效果的预测。方法 :用改良苄胺唑啉 U PP试验将 BPH患者分为阳性及阴性组 ,比较 U PP图诸参数之差异。结果 :143例 BPH患者行改良苄胺唑啉 U PP试验 ,阳性 6 4例 ,占全部病例 (4 5 7例 )的 14.0 %。资料完整者阳性组 (38例 )及阴性组 (2 8例 )试验前最大尿流率(Qmax,m l/s)及 UPP诸参数无显著性差异 (P>0 .0 5 ) ,阳性组 Qmax增加、U PP诸参数减少有显著性差异 (P<0 .0 1)。阳性组试验前后相比膀胱颈压及前列腺部压力降低低于膜部 ,试验后此两处压力相对值增高。 结论 :用 UPP图形不能代替苄胺唑啉U PP试验来预测 BPH患者 α受体阻滞剂治疗效果 ,BPH伴功能性梗阻者对
Objective: To evaluate the relationship between UPP patterns and the therapeutic value of alpha blockers on BPH patients. Methods: By means of modified phentolamine UPP test, patients with BPH were divided into positive and negative groups, and their UPP parametres were compared and analysed. Results: Sixty four cases, approximately 14% of the 457 patients with BPH undergoing comprehensive urodynamic evaluation, had a positive phentolamine UPP test, implying internal sphincter functional obstruction. No significant differences were found in prephentolamine Q max and various UPP parameters between the 2 groups. Whereas there were a great increase in Q max , and a decrease in UPP parameters in the positive group. The pressure drop in bladder neck and prostate portion were lower than those in the membranous portion, either absolutely or relatively. Conclusion: It is the modified phentolamine UPP test, not the prephentolamine UPP patterns that can predict the therapeutic value of alpha blockers on BPH patients. The most alpha blocker sensitive region may be the distal urethral sphincter in patients with BPH accompanied with internal sphincter functional obstruction.
出处
《第二军医大学学报》
CSCD
北大核心
2000年第5期441-443,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金资助项目!(39880045)
关键词
前列腺增长
尿道压力分布图
Α受体阻滞剂
benign prostatic hyperplasia
urodynamics
urethral pressure profile
