摘要
目的 了解抗Ⅱ型胶原抗体在类风湿关节炎 (RA)中的临床意义。方法 以改进的酶联免疫吸附法 (ELISA)检测 179例RA患者和 171例其他风湿病患者的血清IgG型抗天然及抗变性Ⅱ型胶原抗体水平。结果 RA患者抗天然和抗变性Ⅱ型胶原抗体阳性率各为 2 2 3%和 36 9% ,早期RA患者各为 30 0 %和 36 7%。其他风湿病患者中各为 3 5 %和 31 6 % ,健康人二者均为2 5 %。抗天然Ⅱ型胶原抗体阳性RA患者类风湿因子检出率、患者对病情活动性评价高于阴性组(P <0 0 5 )。抗变性Ⅱ型胶原抗体和抗天然Ⅱ型胶原抗体同时阳性RA患者的CRP平均水平较高。结论 抗天然Ⅱ型胶原抗体可以作为RA的一个辅助诊断指标。
Objective To investigate the clinical significance of anti type Ⅱ collagens antibody in rheumatoid arthritis (RA).Method Serum IgG antibodies to native and denatured type Ⅱ collagens (anti nc Ⅱ and anti dc Ⅱ) were detected in 179 patients with RA by an improved enzyme linked immunosorbent assay (ELISA),and their clinical significance was analysed with corresponding clinical materials.Results In RA,the positive rates of anti nc Ⅱ and anti dc Ⅱ were 22 3% and 36 9%;in early RA were 30 0% and 36 7%,respectively.In other rheumatic diseases the positive rates were 3 5% and 31 6%,respectively and were both 2 5% in healthy controls.Anti nc Ⅱ positive RA showed higher prevalence rate of RF and higher scores of patient′s global assessment of disease activity ( P <0 05).The presence of anti nc Ⅱ and anti dc Ⅱ concomitantly was associated with high CRP level in RA patients.Conclusion Anti nc Ⅱ could serve as a supplemental parameter in diagnosing RA and together with anti dc Ⅱ may help evaluate the disease activity.
出处
《风湿病学杂志》
CAS
CSCD
2000年第3期150-152,共3页
关键词
类风湿性关节炎
抗Ⅱ型胶原抗体
ELISA
C反应蛋
Rheumatoid arthritis
Anti type Ⅱ collagen antibody
Enzyme linked immunosorbent assay
C reactive protein
