摘要
我们应用甲基胆蒽诱导小鼠宫颈癌的动物模型,研究了人精液和从宫颈癌病人宫颈部分离的阴道杆菌培养滤液(SB)的肿意促进作用。发现用SB处理的小鼠就可诱导宫颈癌的发生,癌发率达12%,可以诱导Raji细胞EB病毒早期抗原表达阳性的精液和革兰氏阳性杆菌滤液能协同甲基胆蒽诱导宫颈癌,其癌发率从甲基胆蒽的11.8%增到54.2%。单用甲基胆蒽和与SB合用,两者之间差异有显著性意义。实验结果提示,SB具有复合致癌因子,对其机制进行了探讨。
The effect of human semen and culture fluid of bacteria(SB)isolated from thecervix of carcinoma patients on the induction of cervical carcinoma by 20-methylchola-nthrene(MCA)in mice was studied.it was found that cervical carcinoma could beinduced by SB with an induction rate of 12%,That by MCA alone was 11.8%whereasthe SB positive for inducing EB virus EA in Raji cells used in combination with MCAgave an induction rate of 54.2%.The experimental results indicated that SB was bothcarcinogenic and tumor promoting,The possible mechanism of action of SB is discussed.
作者
孙瑜
刘朝奇
王志洁
李新志
张有新
曾毅
Sun Yu(Institute of Virology,Hubei Medieal College,Wuhan)
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1990年第6期401-403,共3页
Chinese Journal of Oncology
