摘要
目的研究卡托普利脉冲缓释微丸(简称Cap脉冲微丸)在Wistar大鼠体内的药动学。方法制备卡托普利脉冲缓释微丸,采用RP-HPLC测定12只Wistar大鼠口服复方卡托普利脉冲缓释微丸胶囊及复方卡托普利片后在不同时间血浆中卡托普利的浓度,通过DAS2.1程序计算药动学参数。结果大鼠体内时滞时间为4.75 h,与普通片剂相比,具有明显时滞,达峰时间明显延长(9.67 h),相对生物利用度(117.29±46.87)%。结论卡托普利脉冲缓释微丸在体内外经明显的时滞后均能缓慢释放,可达到睡前服药,凌晨发挥药效的目的。
OBJECTIVE Compared with the compound captopril tablets （compound Cap）, to study the pharmacokinetics charac- teristics and bioavailability in twelve wista rats after oral administration of Cap pulsed pellets and compound CAP tablets by HPLC. METHODS To prepare captopril pulsed pellets （ Cap pulsed pellets）. The pharmacokinetic parameters were computed by software program DAS2. 1. RESULTS In vivo the lag time for 4. 75 h, compared with ordinary tablet, it has an obviously lag time, tmax was 9.67 h and the relative bioavailability was （ 117.29 ± 46. 87 ） %. CONCLUSION The release of CAP from CAP pulsed sus- tained-release pellets was shown to be sustained-release after an conspicuous lag time in vitro and in vivo. So the drug can be taken by the patient before sleeping and can achieve the purpose in the morning.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2012年第15期1219-1223,共5页
Chinese Pharmaceutical Journal
关键词
卡托普利
脉冲微丸
生物利用度
缓释
captopril
pulse mieropill
bioavailability
slow-release
