摘要
目的:研究枸杞多糖(LBP)对2型糖尿病人血糖及其胰岛素抵抗相关细胞因子的作用。方法:采用1:1匹配法选取年龄相差不超过5岁,糖尿病病程相差不超过5年,服药类型和剂量相近的糖尿病患者,分别服用LBP胶囊(300mg/d,持续3个月)和安慰剂进行干预和统计分析。结果:干预前后两组人群的血糖、肿瘤坏死因子α(TNF-α)变化有统计学差异。两组的瘦素、白细胞介素-6(IL-6)、脂联素和C反应蛋白变化无统计学差异。结论:LBP能够通过抑制TNF-α水平缓解2型糖尿病患者的胰岛素抵抗,从而降低血糖。
Objective： To study the effect of Lycium barbarum polysaccbaride （LBP） on hypoglycemic activity and cytokine in type 2 diabetic patients. Methods： The 1：1 matching method was used to select subjects according to their age （difference no more than 5 years old）, duration of diabetes （difference no more than 5 years） and drug type and doses. LBP or placebo was provided by 300 mg/d for 3 consecutive months. Results： Fasting serum glucose and TNF- α had a significant difference between two groups after administration for 3 months. However, no significant difference was observed in leptin, interleukin 6 （IL-6）, adiponectin and C reactive protein. Conclusion： LBP has the functions of decreasing serum glucose and reducing TNF- α in type 2 diabetic patients.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2012年第13期259-262,共4页
Food Science
基金
国家自然科学基金项目(30872119)
高等学校博士学科点专项科研基金项目(20100092110039)
关键词
枸杞多糖
2型糖尿病
血糖
Lycium barbarum polysaccharide
type 2 diabetes
glucose
