摘要
目的探讨COX-2在非小细胞肺癌(NSCLC)中的表达及意义。方法应用免疫组化方法检测88例非小细胞肺癌、23例癌旁正常肺组织中COX-2蛋白表达水平。结果与癌旁及正常肺组织相比,非小细胞肺癌癌组织中COX-2蛋白表达明显上调(P<0.01),COX-2蛋白表达与患者年龄、性别、有无淋巴结转移等因素无明显相关性,但与临床分期、病理组织学类型相关,肺腺癌组织中表达明显多于其他类型非小细胞肺癌。结论 COX-2蛋白在NSCLC中、特别是肺腺癌中表达上调,可探索用于预测NSCLC患者预后的指标。
Objective To study the expression and significance of COX-2 in non-small cell lung cancer（NSCLC）.Methods The expression of protein COX-2 was detected by immunohistochemistry technique in 88 NSCLC tissues and 23 normal lung cancer tissues.Results The expression of protein COX-2 in NSCLC was significantly higher than that in normal cancer tissues（P〈0.01）.The expression of protein COX-2 was correlated with the clinical staging and histological type,but was not correlated with the age,sex and transferred lymph node of the patients.Compared with other NSCLC,the expression of protein COX-2 was obviously increased in adenocarcinomas cell carcinomas.Conclusion The expression of protein COX-2 is up-regulated in NSCLC,especially in adenocarcinomas cell carcinomas.The expression of protein COX-2 could be valuable indicators for predicting the prognosis of NSCLC.
出处
《实用临床医药杂志》
CAS
2012年第11期121-122,共2页
Journal of Clinical Medicine in Practice
