摘要
目的评价口服糖皮质激素-醋酸泼尼松片治疗慢性阻塞性肺疾病(COPD)急性加重期的疗效及安全性。方法选择89例COPD急性加重期住院患者随机分为2组,对照组常规处理;观察组采用醋酸泼尼松片治疗,15 mg/次,2次/d,连续14 d。观察2组患者治疗前后肺功能、动脉血气变化及不良反应。结果与对照组比较,观察组在治疗后动脉血气及肺功能方面获得了显著改善,差异存在统计学意义(P<0.05),且不良反应少,停药后基本消失。结论观察组的疗效明显优于对照组,醋酸泼尼松片可作为COPD急性加重治疗的有效选择,值得在临床上推广。
Objective To observe the therapeutic efficacy and safety of oral intake of gluco- cortieoid and prednisone acetate tablets on acute exacerbation of chronic obstructive pulmonary dis- ease （COPD）. Methods A total of 89 patients with acute exacerbation of COPD were randomly di- vided into two groups. The control group received conventional treatment and the observation group received prednisone acetate tablets （15 mg/time, 2 times a day, continuous intake for 14 d）. The lung function, arterial blood gas and adverse reactions were observed. Results Compared with the control group, the lung function and arterial blood gas were greatly improved in the observation group. The differences were statistically significant （P 〈 0.05）. Besides, it had less adverse reac- tions and the adverse reactions almost disappeared after stopping medication. The therapeutic effica- cy of the observation group was better than that of the control group. Conclusion Prednisone ac- etate tablets may be taken as an effective selection in the treatment of acute exacerbation stage of COPD, and is worthy of further clinical popularization.
出处
《实用临床医药杂志》
CAS
2012年第9期76-78,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220037)
关键词
慢性阻塞性肺疾病
醋酸泼尼松
肺功能
动脉血气
chronic obstructive pulmonary disease
acute exacerbation
prednisone ac-etate
pulmonary function
arterial blood gas
