摘要
目的检测糖尿病前期合并高血压患者早期肾损伤的敏感检测指标。方法选取健康对照(NGT)组、高血压合并糖耐量减低(IGT)组、高血压合并空腹血糖受损且糖耐量减低(IFG/IGT)组,每组各检测100例。测定各受试者尿液N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、β-D半乳糖苷酶(GAL)活性,测定尿β2-微球蛋白(β2-MG)、尿半胱氨酸蛋白酶抑制剂C(Cystatin C)、尿微量清蛋白(mALB)浓度、血清尿素氮、肌酐浓度,并镜检尿红细胞数量。结果高血压合并IGT组、高血压合并IFG/IGT组的尿NAG、GAL活性、尿β2-MG浓度、尿Cystatin C浓度均高于NGT组(P值均小于0.05)。并比较IGT组、IFG/IGT组的阳性(异常例数)检出率,发现尿NAG、GAL、β2-MG、尿Cystatin C的阳性检出率均显著大于尿微量清蛋白、尿红细胞、血清尿素氮、肌酐的阳性检出率(P值均小于0.05)。结论联合检测尿NAG、GAL、β2-MG、Cystatin C是发现糖尿病前期合并高血压患者早期肾损伤的敏感检测指标。
Objective To investigate the sensitive indexes of the early renal damage of patients with pre-diabetes and hypertension.Methods Patients were divided into three groups,including healthy control groups（NGT,n=100）,hypertension combination IGT groups（n=100）,hypertension combination IFG/IGT groups（n=100）.The activation of urine NAG,GAL and the concentrations of urineβ2-MG,Cystatin C,mALB and the concentrations of fasting serum BUN,creatinine were detected.The amount of red blood cell were counted by microscope.Results The activation of urine NAG,GAL and the concentrations of urine β2-MG,Cystatin C were obviously increased in IGT groups and IFG/IGT groups than those in healthy control（NGT） groups（P〈0.05）.The percentages of positive（abnormal cases） were compared among IGT groups and IFG/IGT groups.The percentages of positive of urine NAG,GAL,β2-MG,cystatin C were obviously increased than those of mALB,red blood cell,BUN,Creatinine（P〈0.05）.Conclusion The combined detection of the concentrations of urine NAG,GAL and urine β2-MG,cystatin C is the sensitive index of the early renal damage of patients with pre-diabetes and hypertension.
出处
《检验医学与临床》
CAS
2012年第14期1697-1698,共2页
Laboratory Medicine and Clinic
关键词
糖尿病前期合并高血压
早期肾损伤
敏感检测指标
pre-diabetes combined with hypertension； early renal damage； sensitive index；
