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高危型HPV与Survivin基因在CIN和SCC诊断预测中的临床意义 被引量：3

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摘要 宫颈癌（squamous cervical cancer,SCC）的发生、发展与人乳头瘤病毒（human papilloma virusHPV）感染和细胞凋亡的调控有密切的关系[1]。许多研究表明,高危型人乳头瘤病毒（HR-HPV）是导致宫颈癌的主要原因[2]为了进一步提高早期诊断率,有必要寻找更为客观、可靠的指标。
作者 张桂荣 何凯 毛慧玲
机构地区 齐齐哈尔医学院第五附属医院(大庆龙南医院)
出处 《中国实验诊断学》 2012年第7期1293-1294,共2页 Chinese Journal of Laboratory Diagnosis
关键词 SURVIVIN基因 早期诊断率 高危型HPV 临床意义 高危型人乳头瘤病毒 SCC CIN 预测
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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  • 2何慧仪,卢丽娜,杜洪,朱秋云,方艺川,陈倩文.Ki67、Survivin、P16表达在宫颈癌和宫颈癌前病变诊断中的意义[J].中国妇幼保健,2006,21(13):1825-1827. 被引量：34
  • 3Lee JP, Chang KH, Han JH, et al Survivin, a novel antiapoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors~ J~. Int J Gynecol Cancer, 2005, (1) :113.
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二级参考文献29

  • 1李婷,刘凤英,徐晓明,吴鼎文,刘毅智,吴宜林.Survivin与高危型人乳头瘤病毒在宫颈癌及癌前病变中的表达和意义[J].实用妇产科杂志,2005,21(2):106-109. 被引量：14
  • 2Ishiji T. Molecular mechanism of carcinogenesis by human papillomavirus-16. J Dermatol, 2000, 27(2): 73-86.
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  • 7Smith JS, Herrero R, Bosetti C, et al. Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst, 2002, 94(21): 1604-1613.
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  • 9An HJ, Cho NH, Lee SY, et al. Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method. Cancer, 2003, 97(7): 1672-1680.
  • 10Cuzick J, Terry G, Ho L, et al. Association between high-risk HPV types, HLA DRB1 and DQB1 alleles and cervical cancer in British women. Br J Cancer, 2000, 82(7): 1348-1352.

共引文献63

同被引文献46

  • 1褚静萍,王言奎.Survivin在宫颈鳞癌组织中的表达及其与p53基因表达及HPV感染相关性[J].中国癌症杂志,2006,16(11):915-918. 被引量：1
  • 2Indarti J, Aziz MF, Suryawati B, et al. Scoring system and management algorithm assessing the role of survivin expression in predicting progressivity of HPV infections in precancerous cervical lesions[J]. Asian Pac J Cancer Prey, 2013, 140): 1643-t637.
  • 3Wu SF, Zhang JW, Qian WY, et al. Altered expression of survivin, Fas and FasL contributed to cervicalcancer development and metastasis[J]. Eur Rev Med Pharmaol Sci, 2012, 16(15): 2044-2050.
  • 4Mita AC, Mita MM, Nawrocki ST, et al. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics[J]. Clin Cancer Res, 2008, 14: 5000-5005.
  • 5Bache M, Holzapfel D, Kappler M, et al. Survivin protein expression and hypoxia in advanced cervical carcinoma Of patients treated by radiotherapy[J]. Gynecol Oncol, 2007, 104(1): 139-144.
  • 6Xue Y, Art R, Zhang D, et al. Detection of survivin expression in cervical cancer cells using molecular beacon imaging: new strategy for the diagnosis of cervical cancer[J]. Eur J Obstet G-ynecol Reprod Biol, 2011, 159(1): 204-208.
  • 7Saitoh Y, Yaginuma Y, Ishikawa M, et al. Analysis ofBcl2, Bax and survivin genes in uterine cancer[J]. International Journal of Oncology, 1999, 15(1): 137-141.
  • 8Branca M, Giorgi C, Santini D, et al. Survivin as a Marker of Cervical Intraepithelial Neoplasia and High-Risk Human Papillomavirus and a Predictor of Virus Clearance and Prognosis in Cervical Cancer[J]. Am J Clin Pathol, 2005, 124(1): 113-121.
  • 9Lu D, Qian J, Yin X, et al. Expression of PTEN and survivin in cervical cancer: promising biological markers for early diagnosis and prognostic evaluation[J]. Br J Biomed Sci, 2012, 69(4): 143-146.
  • 10Bathe M, Holzapfel D, Kappler M, et al. Survivin protein expression and hypoxia in advanced cervical carcinoma of treated by radiotherapy[J]. Gyneeol Oneol, 2007, 104(1): 139.

引证文献3

二级引证文献12

中国实验诊断学
2012年 第7期

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