摘要
目的检测我国健康成年人呼出气一氧化氮（FENO）水平的正常值，并分析其影响因素。方法按照预设的入选及排除标准共人选2011年2—8月在中日友好医院门诊常规体检的非吸烟健康成年受试者，要求肺功能检查指标正常，常见过敏原皮肤点刺试验阴性。按照美国胸科协会／欧洲呼吸病学会推荐的标准操作流程，使用NIOXMINO测定仪对受试者FENO水平进行检测及分析。结果共人选非吸烟健康成年人200名，其中男、女各100名。平均FENO水平为（14．2±5．6）×10。mol／L），95％参考值范围为（3．2～25．2）×10^-9mol／L；其中男性为（15．64-5．5）×10^-9mol／L，女性为（12．9±5．4）×10^-9mol／L，差异有统计学意义（t=3．48，P=0．001）；60～80岁者为（15．7±5．4）×10^-9mol／L，18～60岁者为（13．8±5．6）×10^-9mol／L，差异有统计学意义（t=2．04，P=0．040）。多元回归分析发现性别是其独立影响因素（β=2．70，F=11.97，P=0．001）。结论我国非吸烟健康成年人的FENO水平与欧美相近，性别是其独立影响因素。
Objective To evaluate the normal values of fractional exhaled nitric oxide （FENO） for Chinese adults. Methods A total of 200 non-smoking and healthy Chinese adults were recruited according to the inclusion and exclusion criteria. They received lung function and allergen skin prick tests at the Outpatient Department of China-Japan Friendship Hospital from February to August 2011. There were 100 males and 100 females. FENO test was performed according to the standard procedures of American Thoracic Society/ European Respiratory Society （ATS/ERS） recommendation. The FENO levels of healthy non-smokers were tested by the NIOXMINO analyzer. All variables, such as age, gender, height, weight, forced expiratory volume at 1 second （ FEV, ） % predicted and FEV1/FVC, were included for multiple regression analyses. Results The FENO level of healthy non-smokers was （ 14. 2±5.6）x10^-9mol/Lwith the 95% normal range of （3. 2 -25. 2）x10^-9mol/L. The value of FENO was significantly higher in males than fen：tales （（15. 6±5.5） vs （ 12. 9±5.4）x10^-9mol/L, t = 3.48, P = 0. 001 ）. The FENO level of the subjects aged 60 - 80 years was （ 15.7±5.4）x10^-9mol/L and it was higher than those aged 18 -60 years （ （13.8±5.6） x10^-9mol/L, t = 2.04, P = 0. 040）. Multiple regression analysis showed that gender was an independent influencing factor of FENO level. Conclusions The FENO level of non-smoking and healthy Chinese adults is similar with that of the westerners. Gender is an independent influencing factor of FENO level.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2012年第28期1971-1973,共3页
National Medical Journal of China
关键词
一氧化氮
参考值
呼气
健康受试者
Nitric oxide
Reference values
Exhalation
Healthy subjects
