摘要
目的:探讨不能手术或不愿手术的局部进展期胃癌行同步放化疗的疗效、不良反应。方法:选择不能手术或不愿手术的局部进展期胃癌患者16例,给予DLF方案化疗2周期,同步行病灶以及胃周淋巴结区域放疗DT 45-50.4Gy/1.8-2.0Gy。治疗期间评价不良反应,治疗结束后1个月开始评价疗效,每两个月随访一次。结果:16例患者全部完成治疗,客观缓解率为75%;患者梗阻、疼痛、出血的症状缓解率分别为:80.0%(12/15),83.3%(5/6),100%(1/1)。中位进展时间为6个月,中位生存期为7个月,生存期范围:5-18个月。不良反应主要为I-II级血液学和消化道反应。结论:局部进展期胃癌选用DLF方案同步放疗疗效较好,不良反应可以耐受,值得进一步推广。
Objective：To evaluate the efficacy and adverse effect of chemoradiotheray for inoperable patients or who did not want to be operated local advanced gastric cancer. Methods：Sixteen inoperable or who did not want to be operated local advanced gastric cancer patients were selected. All patients received two cycles of DLF ehemotheray. The irradiation target was local - reginoal focus and lymph nodes surrounding stamoch. The radiation dose ranged form 40 to 50.4Gy in daily 1.8 - 2.0Gy fractions, 5 times weekly. We evaluted adverse effeetion during treatment, and treatment efficacy at a month after completing treatment. Results： All patients were completed treatment. ORR was 75 %. The remission rate of dysphagia/obstruction, bleeding and pain were 80.0% （ 12/15 ） ,83.3 % （5/6）and 100% （ 1/1 ）. The median progression was 6 months. The median survival was 7 months. The survival ranged from 3 - 18 months. Conclusion：The treatment efficacy of DLF chemotherapy plus radiotherapy for local gastric carcinoma was good. The major adverse effects were tolerable.
出处
《现代肿瘤医学》
CAS
2012年第8期1659-1662,共4页
Journal of Modern Oncology
关键词
胃癌
晚期
放射疗法
化学疗法
gastric cancer
advanced stage
radiotherapy
chemotherapy
