摘要
目的 研究表皮生长因子受体 (EGFR)、C- erb B- 2原癌基因在乳腺癌组织中的表达 ,探讨其与乳腺癌骨髓微小转移间的关系及对乳腺癌患者预后的影响。方法 选择 42例乳腺癌患者石蜡固定的组织标本 ,用 SABC免疫组织化学方法检测 EGFR、C- erb B- 2蛋白。采用 χ2检验。结果 EGFR阳性 42 .9% ,C- erb B- 2阳性 31%。EGFR与 C- erb B- 2两者间无显著关系。随访的 2 6例患者中 ,EGFR、C- erb B- 2阳性与阴性间术后 5年生存率有明显差别。结论 EGFR、C- erb B- 2表达与乳腺癌骨髓微小转移有密切关系 ,可以作为判断乳腺癌预后的重要指标。乳腺癌组织中 EGFR、C- erb B- 2阳性患者预后不良。
Objective To investigate the expression of epidermal growth factor receptor (EGFR) and C erbB 2 proteins in breast cancer, and to search the relation between micrometastasis in bone marrow and the above facts. Methods SABC immunocytochemical assay for EGFR and C erbB 2 proteins were made on paraffin embedded section. The statistical analyses were performed using chi square test. Results Overall, 42.9% of the tumors were EGFR proteins positive.C erbB 2 proteins were positive in 31% of the tumors. The positivity of both EGFR and C erbB 2 proteins was significantly connected to that of micrometastasis in bone marrow. The positivity of EGFR proteins was not related to that of C erbB 2 proteins. The follow up period of 26 patients was 60 months. The overall survival was worse in patients with EGFR, C erbB 2 proteins positive tumors compared with EGFR, C erbB 2 proteins negative tumors. Conclusion EGFR, C erbB 2 proteins are significantly related to micrometastasies in bone marrow. Multivariate analyses show that both EGFR and C erbB 2 proteins positive are two key prognostic factors in breast cancer patients. [WT5,5”HZ]
出处
《南京医科大学学报（自然科学版）》
CSCD
2000年第1期7-10,共4页
Journal of Nanjing Medical University(Natural Sciences)
