摘要
目的探讨聚焦超声治疗婴幼儿血管瘤的效果及适宜能量参数。方法80例婴幼儿血管瘤采用区组随机分组法分成4组，每组20例，A、B、C3组采用聚焦超声治疗仪以3～5mm／s速度连续辐照血管瘤表面，频率9MHz，脉冲1000Hz，重叠10％，扫描5个来回，功率分别为3．5、4．0、4．5W，治疗3次为1个疗程，每次治疗间隔1个月，D组为空白对照组，仅随访观察。观察A、B、C3组治疗结束6个月后效果及辐照区皮肤破溃、瘢痕发生率，并与D组同期结果对照。结果1个疗程结束6个月后，A、B、C3组分别治愈7、9、8例，基本治愈9、8、10例，好转4、3、2例，总有效率均为100％，D组仅好转5例，经统计学分析，A、B、c3组治疗效果明显好于D组（P〈0．05），但A、B、C3组间治疗效果比较差异无统计学意义（P〉0．05）；B、C组分别有4、6例出现皮肤破溃及瘢痕，经统计学分析B、c组皮肤破溃及瘢痕发生率明显高于A、D组（P〈0．05）。结论聚焦超声辐照是治疗婴幼儿血管瘤的有效方法之一，能量以不超过3．5W为宜。
Objective To explore the clinical effect and appropriate power of high-intensity focused ultrasound（HIFU） in the treatment of infant hemangioma. Methods 80 infants with hemangioma were randomly divided into four groups, 20 cases in each group. All cases in group A, B and C were irradiated on the lesion surface with 3-5 mm/s speed for five continuous come-and-goes using HIFU, with frequency 9 MHz, impulse 1 000 Hz and 10% scanning overlap. The power was respectively 3.5 W in group A, 4.0 W in group B and 4.5 W in group C. One session contained three times of treatment, with one month interval. The cases in group D were only followed up as control group. The therapeutic effect, ulcer and scar in irradiated region in group A, B, C were observed 6 months after the last treatment, which were synchronously compared with those in group D. Results 6 months after the last treatmen, 7, 9, 8 cases were cured and 9, 8, 10 cases were almost cured, and 4, 3, 2 cases got improved in group A , B, C, respectively. The total effective rate was 100% in the three groups. While only 5 cases got improved in group D. The treatment effect in group A,B and C was obviously better than that in group D （ P 〈 0. 05 ） , with no significant difference among the three groups statistically（ P 〉0.05 ）. Ulcer and scar in irradiated skin occurred in 0,4,6,0 cases in group A, B, C and D, respectively. The incidence of ulcer and scar was obviously higher in group B and C than that in group A and D statistically （ P 〈 0.05 ）. Conclusions HIFU irradiating is one of effective methods for infant hemangioma treatment. The appropriate power should not be above 3.5 W.
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2012年第4期252-255,共4页
Chinese Journal of Plastic Surgery
关键词
血管瘤
血管疾病
聚焦超声
H：emangioma
Vascular disease
Focused ultrasound
