摘要
目的了解我国南海官兵所生活岛礁的甲、乙、丙和戊型肝炎病毒分布情况。评估感染风险度,制定预防措施。方法 (1)上礁前,采集158名将上岛守礁官兵血清样本,进行常规肝炎病毒检测。(2)无菌采集上述158名上岛礁3个月后官兵的血液样本和礁上物体表面生理盐水样本390份,共548份。收集后保存于-20℃冰柜中,立即随补给船送回实验室进行乙型肝炎病毒DNA和甲、丙、戊型肝炎病毒RNA检测。结果 (1)158名守礁官兵上礁前检出血清甲肝抗体(lgG)阳性5人(3.16%);乙肝病毒表面抗原、丙肝和戊型肝炎抗体检测均为阴性。(2)上礁3个月以后,158份血清样本检出甲肝抗体阳性7份(4.43%),其中lgG阳性5份,lgM阳性2份(甲肝RNA为阳性);乙肝DNA检测有2份阳性(1.27%)。丙肝和戊型肝炎病毒RNA均为阴性。390份礁上的物体表面样本:检出甲、丙、戊肝病毒RNA阳性分别为24份(6.15%)、3份(0.77%)、2份(0.51%);乙肝病毒DNA阳性5份(1.28%)。结论守礁官兵所驻岛礁生活环境中存在甲、乙、丙、戊肝传染源,卫生部门要提高认识,有效地控制传染源,培养官兵良好的生活习惯,切断传染途径,预防守礁官兵病毒性肝炎传播和流行,并制定相应的病毒性肝炎流行治疗预案,配备治疗药品。
Objective To investigate the distribution of hepatitis A, B, C and E viruses among the garrison officers and men stationed in the Islets in the South China Sea, to evaluate the risks of hepatitis infection and also to develop preventive effective measures. Methods （ 1 ） One hundred and fifty-eight serum samples of the officers and men were collected for laboratory routine detection of hepatitis viruses, before deployment. （2） After 3 months of deployment to the islets, 158 serum samples and 390 samples of saline samples from islet surface objects （totaling 548 samples） were collected with aseptic technique and stored in the -20℃ icebox. Then, all the samples were brought back as soon as possible by the auxiliary ship and sent to the laboratory for HBV DNA detection and HCV, HAV, HEV RNA detection. Results Medical detection before deployment to the islets indicated that there were 5 cases （3.16%） of positive serum hepatitis A anti-body in 158 officers and men, while detections of hepatitis B surface antigen （HBsAg） , hepatitis C and E antibodies were all negative. （2） After 3 months of deployment to the islets, there were 7 positive hepatitis A anti-body cases （4.43%）, of which 5 cases were lgG positive and 2 cases were lgM positive （ hepatitis A RNA was positive） in 158 serum samples; There were 2 hepatitis B DNA positive cases （ 1.27% ）. Hepatitis C and E virus RNA detections were all negative. Laboratory tests of the 390 samples from the islet surface objects showed that hepatitis A, C and E RNA positive cases were 24（6.15% ） , 3（0.77% ） and 2 （0.51%）. Hepatitis B DNA positive cases were 5 （1.28%）. Conclusion There were sources of infection of hepatitis A, B, C and E in the islets where the officers and men stayed. Medical personnel should be highly aware that sources of infection should be controlled, route of transmission be cut off and good life habit be formed, so that transmission and prevalence of virus hepatitis could be prevented. Therapeutic profiles for the treatment of epidemic virus hepatitis should be developed and dru^s be kept in store for possible prevalence of hepatitis.
出处
《海军医学杂志》
2012年第4期266-269,共4页
Journal of Navy Medicine
