摘要
目的:研究影响大鼠心梗模型存活率的因素。方法:采用正交实验,以不同插管方式(经口插管,切开插管)、麻药(水合氯醛,乌拉坦)、是否采用利多卡因设计三因素两水平方案,观察大鼠插管后心率、术中死亡率、围手术期死亡率、总死亡率、室性心律失常放生率、发生室性心律失常大鼠死亡率、术后感染率。结果:插管方式是插管后心率、术中死亡率、总死亡率的主要因素,是否采用利多卡因是围手术期死亡的主要因素,不同麻醉剂是大鼠室性心律失常发生率的主要因素。发生室性心律失常大鼠与心率失常后死亡率有明显的相关性。水合氯醛麻醉与是否采用利多卡因是影响大鼠围手术期死亡率的主要因素。大鼠术后感染与不同插管方式,麻醉剂、利多卡因无关。结论:对于初作者采用气管切开插管、水合氯醛联合利多卡因是可以采用的试验方案。
Objective：To study the factors of the survival rate of rat myocardial infarction model.Methods：The orthogonal test was used in different ways：intubation（oral intubation,incision intubation）,anesthesia（chloral hydrate,urethane）,whether to adopt the three factors and two levels of lidocaine design program,heart rate after intubation,intraoperative mortality,perioperative mortality,total mortality,ventricular arrhythmias release rate,the occurrence of ventricular arrhythmias in rat mortality and postoperative infection rates.Results：The intubation method was the main factor of the heart rate after intubation,intraoperative mortality and total mortality.The use of lidocaine was the main factor of the perioperative death.Different anesthetic was the main factor of the ventricular arrhythmias.Ventricular arrhythmia and cardiac arrhythmias in rats had the obvious correlation.Chloral hydrate anesthesia with or without lidocaine was the main factor of perioperative death.Intubated rats were infected with different methods,however anesthetic and lidocaine had nothing to do.Conclusion：For the patients who is be operated for the first time,tracheotomy tube and chloral hydrate with lidocaine can be used for the test design.
出处
《中华中医药学刊》
CAS
2012年第7期1500-1502,I0001,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30973717,30772696)
湖南中医药大学青年教师资助项目(48010101-1)
关键词
心梗模型
大鼠
存活率
myocardial infarction model
rats
survival rate
