期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂联素及其受体抗肿瘤的研究进展 被引量：7

Research Progress in Regulation of Adiponectin and its Receptor Anti-tumor
原文传递
导出
摘要 目前大量的研究已表明循环系统的脂联素浓度与恶性肿瘤的发病风险呈负相关。这些恶性肿瘤包括绝经后乳腺癌、子宫内膜癌、大肠癌、前列腺癌等。脂联素是在其受体(AdipoR1和AdipoR2)的介导下发挥其生物学作用。相关实验发现,AdipoR1/R2在乳腺癌、子宫内膜癌、结直肠癌等肿瘤组织中有表达。因此针对脂联素的研究可能揭示其与恶性肿瘤的发生、发展的相关性。 At present a large number of studies have shown that circulatory adiponectin concentrations are negatively associated with the malignant cancer risk.These malignant tumors including postmenopausal breast cancer,endometrial cancer,colorectal cancer,prostate cancer,leukemia and so on.These biological effects are mediated by adiponectin receptor 1 and adiponectin receptor 2.Related experiments found that AdipoR1 / R2 expressed in the organizations of malignant tumors such as breast cancer,endometrial cancer and colorectal cancer.So researches on adiponectin may reveal the relationship between adiponectin and malignant tumor genesis and development.
作者 陈维煜 丛丽
机构地区 哈尔滨医科大学附属第二医院内分泌科
出处 《现代生物医学进展》 CAS 2012年第17期3374-3376,共3页 Progress in Modern Biomedicine
关键词 脂联素 脂联素受体 肿瘤 机制 Adiponectin Adiponectin receptors Malignant tumors Mechanism
分类号 R730.231 [医药卫生—肿瘤]
  • 相关文献

参考文献29

  • 1Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresp- onsiveness[J]. J Allergy C|in Immunol, 2005, 115:925-927.
  • 2Pfeiler G, Treeck O, Wenzel G, et al. Influence of insulin resistance on adiponectin receptor expression in breast cancer [J]. Maturitas, 2009, 63(3):253-256.
  • 3Takemura Y, Osuga Y, Yamauchi T, et al. Expression of adiponectin receptors and its possible implication in the human endomea'ium [J]. Endocrinology, 2006, 147(7):3203-3210.
  • 4Yoneda K, Tomimoto A, Endo H, et al. Expression of adiponeetin rec- eptors, AdipoR1 and AdipoR2, in normal colon epithelium andcolon cancer tissue[J]. Oncol Rep, 2008, 20(3):479-483.
  • 5Petridou E, Mantzoros C, Dessypris N, et al. Plasma adiponectin conc- entrations in relation to cudometriat cancer: a case-control study iaG-r- eece[J]. J Clin Endocrinol Metab, 2003, 88(3):993-997.
  • 6Dal Maso L, Augustin LS, Karalis A, et al. Circulating adiponectin and endometrial cancer risk[J]. J Clin Endoefinol Metab, 2004, 89(3):1160- 1163.
  • 7Soliman PT, Wu D, Tortolero-Luna G, et al. Association between adip- oneetin insulin resistance, and endometrial cancer [J]. Cancer, 2006, 106(11):2376-2381.
  • 8Rzepka-G6rska I, Bedner R, Cymbaluk-Ploska A, et al. Serum adipon- ectin in relation to endometrial cancer and endometrial hyperplasia w- ith atypia in obese women[J]. Eur J GynaecoI Oncol, 2008, 29(6):594- 597.
  • 9张丽志,温克,刘荣,瞿全新.子宫内膜癌患者血清脂联素水平变化及意义[J].山东医药,2010,50(26):4-5. 被引量：11
  • 10lshikawa M, Kitayama J, Kazama S, et al. Plasma adiponectin and gastric cancer[J]. Clin Cancer Res, 2005, 11(2 Pt 1):466-472.

二级参考文献75

  • 1杨丹,韩立敏.1969-2003年子宫内膜癌发病率及发病因素分析[J].复旦学报（医学版）,2005,32(4):479-480. 被引量：33
  • 2[1]Friedman JM.Obesity in the new millennium.Nature 2000; 404:632-634
  • 3[2]Kopelman PG.Obesity as a medical problem.Nature 2000; 404:635-643
  • 4[3]Giovannucci E,Michaud D.The role of obesity and related metabolic disturbances in cancers of the colon,prostate,and pancreas.Gastroenterology 2007; 132:2208-2225
  • 5[4]Spiegelman BM,Flier JS.Obesity and the regulation of energy balance.Cell 2001; 104:531-543
  • 6[5]Shimomura I,Funahashi T,Takahashi M,Maeda K,Kotani K,Nakamura T,Yamashita S,Miura M,Fukuda Y,Takemura K,Tokunaga K,Matsuzawa Y.Enhanced expression of PAI-1 in visceral fat:possible contributor to vascular disease in obesity.Nat Med 1996; 2:800-803
  • 7[6]Scherer PE,Williams S,Fogliano M,Baldini G,Lodish HF.A novel serum protein similar to Clq,produced exclusively in adipocytes.J Biol Chem 1995; 270:26746-26749
  • 8[7]Maeda K,Okubo K,Shimomura L Funahashi T,Matsuzawa Y,Matsubara K.cDNA cloning and expression of a novel adipose specific collagen-like factor,apM1 (AdiPose Most abundant Gene transcript 1).Biochem Biophys Res Coramun 1996; 221:286-289
  • 9[8]Hu E,Liang P,Spiegelman BM.AdipoQ is a novel adiposespecific gene dysregulated in obesity.J Biol Chem 1996; 271:10697-10703
  • 10[9]Arita Y,Kihara S,Ouchi N,Takahashi M,Maeda K,Miyagawa J,Hotta K,Shimomura L Nakamura T,Miyaoka K,Kuriyama H,Nishida M,Yamashita S,Okubo K,Matsubara K,Muraguchi M,Ohmoto Y,Funahashi T,Matsuzawa Y.Paradoxical decrease of an adipose-specific protein,adiponectin,in obesity.Biochem Biophys Res Commun 1999; 257:79-83

共引文献26

同被引文献107

  • 1中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中国糖尿病杂志,2004,12(3):156-161. 被引量：3086
  • 2Reis LO,Sasse AD,Matheus WE,et al.Prostate cancer:evidence based clinical practice[J].Actas Urol Esp,2009,33(4):344-350.
  • 3Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
  • 4Lund HL,Wisloff TF,Holme I,et al.Metabolic syndrome predicts prostate cancer in a cohort of middle-aged Norwegian men followed for 27 years[J].Am J Epidemiol,2006,164(8):769-774.
  • 5Beebe-Dimmer JL,Nock NL,Neslund-Dudas C,et al.Racial differences in risk of prostate cancer associated with metabolic syndrome[J].Urology,2009,74(1):185-190.
  • 6De Nunzio C,Freedland SJ,Miano R,et al.Metabolic syndrome is associated with high grade Gleason score when prostate cancer is diagnosed on biopsy[J].Prostate,2011,71:1492-1498.
  • 7Mondul AM,Clipp S,Helzlsouer KJ,et al.Association between plasma cholesterol concentration and incident prostate cancer in the CLUE cohort[J].Cancer Causes Control,2010,21(1):61-68.
  • 8Wallner LP,Morgenstern H,McGree ME,et al.The effects of metabolic conditions on prostate cancer incidence over 15 years of follow-up:results from the Olmsted County Study[J].BJU Int,2011,107(6):929-935.
  • 9Allott EH,Masko EM,Freedland SJ.Obesity and prostate cancer:weighing the evidence[J].Eur Urol,2013,63(5):800-809.
  • 10Burton A,Martin RM,Holly J,et al.Associations of adiponectin and leptin with stage and grade of PSA detected prostate cancer:the ProtecT study[J].Cancer Causes Control,2013,24(2):323-334.

引证文献7

二级引证文献29

现代生物医学进展
2012年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部