摘要
目的 探讨P53 突变蛋白在乳腺癌原发灶与转移灶中表达差异与其侵袭性之间的关系。方法 用免疫组化ABC法检测了 42例乳腺原发癌与转移癌石蜡切片中 ,P53 蛋白表达情况。结果 乳腺癌P53蛋白的异常表达率为 5 9.5 2 % (2 5 /4 2 )。原发组阳性率为 45 .45 % (10 /2 2 ) ,转移组 75 .0 0 % (15 /2 0 )。≥ 45岁组阳性率 80 .0 0 % (16 /2 0 ) ,<45岁组 40 .91% (9/2 2 )。P53 蛋白表达在乳腺原发癌及转移癌间有显著差异(P <0 .0 5 ) ,与年龄亦显著相关。结论 乳腺原发癌与转移癌之间有明显异质性。
Objective To study the relationship between the different expression of P 53 protein in primary and metastatic human breast carcinoma and its invasiveness. Methods Forty-two paraffine embedded tissue sections were studied with immunohisto-chemical ABC staining to observe P 53 protein expression in original and metastic tumor.Results The abnormal rate of P 53 protein expression was 59.52%(25/42).The original group was 45.45%(10/22), and that of metastatic group was 75.00%(15/20). The positive rate of the patients who are above 45 years old was 80.00%(16/20), while the younger group was 40.91%(9/22).The difference of the rate was significantly in original tumor,metastatic tumor and age. Conclusion The heterogencity lie between the primary breast carcinoma and the metastatic breast carcinoma.
出处
《新乡医学院学报》
CAS
2000年第2期110-112,共3页
Journal of Xinxiang Medical University
基金
新乡医学院第二届大学生科研资助
关键词
原发癌
转移癌
P53蛋白
乳腺癌
breast
primary carcinoma
metastatic carcinoma
P 53 protein
