摘要
目的研究大肠癌Ｐ５３蛋白与Ｐ－糖蛋白表达的相互关系及临床意义。方法通过免疫组织化学方法测定３１例大肠癌Ｐ５３蛋白和Ｐ－糖蛋白的表达。结果其中Ｐ５３蛋白表达阳性者５４．８％；Ｐ－糖蛋白表达阳性者５１．６％。Ｐ－糖蛋白表达阳性者在Ｐ５３蛋白表达阳性组比Ｐ５３蛋白表达阴性组者比率增高（Ｐ＜０．０１）。Ｐ蛋白和Ｐ－糖蛋白表达间呈正相关。结论大肠癌多药耐药性随Ｐ５３阳性率增高而增加。
Objective To study the expression of P 53 protein and p-glycoprotein and its relationship in colorectal carcinoma.Methods Thirty one cases with colorectal cancer were subjected to immunohistochemical to obseve the expression of P 53 protein and p-glycoprotein and its relationship.Results The positive expression of P 53 protein was found in 54.8% and the positive expression of p-glycoprotein was found in 51.6% in colorectal carcinoma.It was indicated that the positive expression rate of P 53 protein with the positive expression of p-glycoprotein was higher than the positive expression rate of P 53 protein with the negative expression of p-glycoprotein in carcinoma (P< 0.01 ).The expression of P 53 protein and p-glycoprotein was interrelated to each other.Conclusions The result show that the P 53 protein correlated with the multidrug resistance in colorectal colorectal carcinoma.
出处
《中国肿瘤临床与康复》
1999年第3期36-36,35,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
大肠肿瘤
P53蛋白
P-糖蛋白
免疫组化
Colorectal carcinoma P 53 Protein P-glycoprotein immunohistochemistry
