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水通道蛋白-2的研究进展 被引量：1

Research Progress in Aquaporin- 2
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摘要 水通道蛋白-2是1993年由日本学者发现的，仅在肾脏集合管表达，受加压素的调节。本文对近年来水通道蛋白-2在尿崩症，糖尿病，水盐代谢紊乱等的病理机制中的作用做综述。 Aquaporin -2 （AQP -2） was found in 1993 by a Japanese researcher. It was a water channel of the apical membrane of the kidney collecting tubule. It was regulated by vasopressin. The progress of AQP - 2 in nephrogenic diabetes insipidus, diabetes millutus, water and salt metabolism in this paper.
作者 杜娟
机构地区 长春市中心医院肾病科
出处 《国际老年医学杂志》 2012年第4期176-181,共6页 International Journal of Geriatrics
基金 吉林省卫生厅科研项目（2009ZC040）
关键词 水通道蛋白-2 尿崩症 糖尿病 水盐代谢紊乱 Aquaporin -2 Nephrogenic diabetes insipidus Diabetes millutus Water and salt metabolism
分类号 R764 [医药卫生—耳鼻咽喉科]
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参考文献45

  • 1Fushimi K, Uchida S, Hara Y, et al. Cloning and expression of apical membrane water channel of rat kidney collecting tubule [J]. Nature, 1993, 361 (6412): 549 - 552.
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二级参考文献10

  • 1Nielsen S,Frokiaer J,Marples D,et al.Aquaporins in the kidney:from molecules to medicine.Physiol Rev,2002,82:205-244.
  • 2Kim D,Sands JM,Klein JD.Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats.Am J Physiol Renal Physiol,2003,285:F303-F309.
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  • 8Kwon TH,Frokiaer J,Knepper MA,et al.Reduced AQP-1,-2,and 3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass.Am J Physiol,1998,275:F724-F741.
  • 9Rai T,Sekine K,Kanno K,et al.Urinary excretion of Aquaporin-2 water channel protein in human and rat.J Am Soc Nephrol,1997,8:1357-1362.
  • 10范亚平,蒋季杰.水通道与肾脏[J].国外医学（泌尿系统分册）,2001,21(5):215-219. 被引量：9

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国际老年医学杂志
2012年 第4期

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