期刊文献+

麻醉与老年人手术后认知功能障碍研究进展 被引量:34

Updated relation of anesthesia with postoperative cognitive dysfunction
暂未订购
导出
摘要 老年人手术后认知功能障碍(postoperative cognitive dysfunction,POCD)发病机制复杂、发病原因不明,现尚无有效防治方法,是目前麻醉学研究热点。麻醉对POCD发生的作用有不同观点,现有研究结果尚不足以进行Meta分析,但提示麻醉对POCD的影响不容忽视。文中就目前麻醉与POCD发生的研究进展做一综述。 Postoperative cognitive dysfunction (POCD), due to its complicated pathogenesis, unclear disease cause and no methods available for its prevention and treatment, has become a focus in current anesthesiologic research. The role of anesthesia in POCD remains controversial, and the results of studies were not adequate for Meta analysis. However, the suggested involvement of anesthesia in POCD cannot be neglected.
出处 《医学研究生学报》 CAS 北大核心 2012年第6期650-653,共4页 Journal of Medical Postgraduates
基金 国家自然科学基金(81171034)
关键词 麻醉 术后认知功能障碍 学习记忆 Anesthesia Postoperative cognitive dysfunction Learning and memory
  • 相关文献

参考文献23

  • 1Moiler JT, Cluitmans P, Rasmussen LS, et al. Long-term post- operative cognitive dysfunction in the elderly. ISPOCD investiga- tors. International study of post-operative cognitive dysfunction [J]. Lancet, 1998, 351(9106) :857-861.
  • 2洪涛,闻大翔,杭燕南.血清S100ββ变化与老年患者腹部手术后认知功能障碍的关系[J].临床麻醉学杂志,2006,22(8):571-573. 被引量:28
  • 3Cancelli I, Gigli G1, Piani A, et al. Drugs with anticholinergic properties as a risk factor for cognitive impairment in elderly peo- ple [ J ]. Clin Psychopharmacol, 2008, 28 (6) :654-659.
  • 4Ancelin ML, Artero S, Portet F, et al. Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs : longitudinal cohort study [ J ]. BMJ, 2006, 332 ( 7539 ) : 455-459.
  • 5Cancelli I, Valentinis L, Merlino G, et al. Drugs with anticho- linergic properties as a risk factor for psychosis in patients affect- ed by alzheimer's disease[ J]. Clin Pharmacol Ther, 2008, 84 ( 1 ) :63-68.
  • 6Amenta F, Tayebati SK. Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cogni- tive dysfunction [J]. Curr Med Chem, 2008, 15 (5) :488-498.
  • 7张捷,吴新民.咪达唑仑对东莨菪碱致大鼠认知功能障碍的影响[J].中华麻醉学杂志,2007,27(2):160-163. 被引量:24
  • 8Kingston S, Mao L, Yang L, et al. Propofol inhibits phosphoryl- ation of N-methyl-D-aspartate receptor NR1 subunits in neurons [ J ]. Anesthesiology, 2006, 104 (4) : 763-769.
  • 9蒯建科,孙绪德,高昌俊,杨永慧,姚立农,柴伟,曹一战.氯胺酮对新生大鼠认知功能和海马突触素表达的影响[J].医学研究生学报,2008,21(4):364-366. 被引量:10
  • 10王娴,杨春,周志强,杨建军,徐建国.核因子-κB介导氯胺酮所致微清蛋白阳性中间神经元表型缺失[J].医学研究生学报,2010,23(7):688-691. 被引量:5

二级参考文献77

共引文献98

同被引文献292

引证文献34

二级引证文献321

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部