摘要
目的 研究儿童过敏性哮喘与血清总 Ig E、尘螨特异性 Ig E、尘螨过敏原皮肤点刺试验的关系。方法 采用双抗体夹心酶联免疫吸附试验 (EL ISA) ,检测了 87例哮喘患儿血清总 Ig E和尘螨特异性 Ig E水平 ,应用国际标准方法做尘螨过敏原皮肤点刺试验 ,并比较了三种检查结果之间的关系。结果 哮喘患儿的血清总 Ig E为 (5 42 .84± 32 1.85 ) IU / m l,尘螨特异性Ig E阳性率为 71.3% ,尘螨过敏原皮肤点刺试验阳性率 83.9% ,正常对照组 42名健康儿童总 Ig E(2 2 1.76± 2 13.73) IU / ml,尘螨特异性 Ig E阳性率 19.0 % ,皮肤点刺试验阳性率 2 3.8% ,三种试验两组间统计学处理有极显著差异 (P<0 .0 1) ;血清总 Ig E增高 (>45 0 IU/ ml)与尘螨特异性 Ig E阳性符合率 91.5 % ;血清尘螨特异性 Ig E阳性与皮肤点刺试验阳性符合率为 75 .6 %。结论 哮喘儿童血清总 Ig E水平、尘螨特异性 Ig E阳性率及尘螨皮肤点刺试验阳性率均明显高于健康儿童。
Objective To study the relationship between children allergic asthma and serum total IgE(tIgE),specific IgE(sIgE) of dust mite,skin prick test (SPT) with dust mite extract.Methods Serum tIgE,sIgE of 87 asrhmatic children were detected by using double antibody ELISA.SPT was performed under the international standard.The relationship among the three results was compared.Results tIgE lecel of asthmatic children was(542 84±321 85)IU/ml.71 3% asthmatic children were positive for sIgE and 83 9% positive for SPT.tIgE level of 42 healthy children was(221 76±213 73)IU/ml,and 19 0% were positive for sIgE,There was an obviously significant difference berween asthmatic children and the controls (P<0 01).High tIgE (>450 IU/ml)was agreement well with the positive rate of sIgE(91 5%).Likewise,the positve rate of sIgE fitted well with SPT(75 6%).Conclusion The level of tIgE,the positive rate of sIgE and SPT in asthmatic children predominated over that in the controls.
出处
《华中医学杂志》
2000年第2期67-68,共2页
Central China Medical Journal
