摘要
目的探讨利培酮联合石杉碱甲对慢性精神分裂症患者认知功能的影响。方法将60例慢性精神分裂症患者随机分为两组,一组为利培酮合并石杉碱甲治疗(研究组),另一组单用利培酮治疗(治疗组),进行为期6个月的治疗观察。治疗前后进行应用事件相关电位P300、韦氏记忆量表(WMS)、韦氏成人智力量表(WAIS-RC)及威斯康星卡片分类测验(WCST)测定所有患者认知功能。选30名健康志愿者(对照组)进行同样相关认知功能测定。结果治疗前两组慢性精神分裂症患者言语智商、操作智商、韦氏记忆商、WCST各项指标成绩均低于正常对照组;P300潜伏期延长、波幅降低。研究组和治疗组治疗前两组评估指标间无显著性差异(P>0.05)。研究组治疗前后P300潜伏期、波幅与神经心理学测验成绩均有明显改善,二者差异有统计学意义(P<0.05)。治疗组治疗前后相关检测间均无显著性变化。结论石杉碱甲能有效改善患者认知功能,对慢性精神分裂症治疗有一定的辅助或增效作用。
Objective To evaluate chronic schizophrenic patients. Methods the effect of huperzine a combined with risperidone on cognitive function in A total of 60 chronic schizophrenic patients were randomly divided into combination treatment group （n = 30） treated with risperidone combined with huperzine a and monotherapy group （n = 30） treated with risperidone for 6 months. All the patients were assessed with P300, Weehsler Memory Scale （WMS） , Wechsler Adult Intelligence Scale （WAIS-RC） and Wisconsin Card Sorting Test （WCST） to evaluate their cognitive function at baseline and at the end of the study. The cognitive function of 30 healthy volunteers （ control group） were assessed with instruments mentioned above. Results Compared with control group, scores of VIQ, PIQ, MQ, WCST in all the chronic schizophrenic patients at baseline were significantly lower （ P 〈 0. 05 ）, the latency period of P300 prolonged significantly and the amplitude decreased significantly. There was no significant difference in all the measurement indexes between combination treatment group and monotherapy group （P 〉 0. 05 ）. Scores of neuropsychological tests, latency period and amplitude of P300 were significantly improved in patients in combination group after the treatment （ P 〈 0.05 ）. However, the improvement was not found in monotherapy group after the treatment （P 〉 0. 05 ）. Conclusion Huperzine a can improve the cognitive function of patients with chronic schizophrenia.
出处
《精神医学杂志》
2012年第3期191-194,共4页
Journal of Psychiatry
基金
上海市虹口区卫生局科研支持课题(编号:虹卫0903-18)
