摘要
目的探讨行为激活疗法对精神分裂症后抑郁的疗效及社会功能的影响。方法将89例精神分裂症后抑郁患者随机分为研究组(45例)和对照组(44例),研究组给予行为激活疗法合并药物治疗,对照组单纯药物治疗,疗程6周,1年后随访,采用汉密尔顿抑郁量表(HAMD)、阳性和阴性综合征量表(PANSS)及社会功能缺陷筛选量表(SDSS)评定疗效。结果两组治疗后第2、4、6周末及治疗后1年HAMD评分均较治疗前下降(P<0.05);研究组治疗后第4、6周末及治疗后1年HAMD评分低于对照组(P<0.01)。两组治疗后第4、6周末及治疗后1年PANSS量表阳性症状和一般病理评分及SDSS量表评分均较治疗前下降(P<0.05),治疗后第2、4、6周末及治疗后1年PANSS量表阴性症状和总分均较治疗前下降(P<0.05);研究组治疗后第4、6周末及治疗后1年PANSS量表阴性症状和总分及SDSS量表评分均低于对照组(P<0.05),研究组治疗后1年PANSS量表阳性症状和一般病理评分均低于对照组(P<0.05)。研究组复发率(7%)低于对照组(25%)(P<0.05)。结论行为激活疗法可以提高精神分裂症后抑郁患者的临床疗效,降低一年后复发率并可改善患者的社会功能。
Objective To explore the influence of behavioral activation therapy on curative effect and social function in patientswithpost-schizophreniadepression.Methods 89patientswithpost-schizophreniadepressionwererandomlydivided into study group （45 cases） treated with medication combined with behavioral activation therapy for 6 weeks and control group （44 cases） only treated with medication for 6 weeks.All patients were followed up 1 year later.The efficacy was evaluated by using Hamilton Depression Scale （HAMD） and Positive and Negative Syndrome Scale （PANSS）, social function was evaluated by using Social Disability Screening Schedule （ SDSS） .Results Scores of HAMD in both groups decreased significantly at the end of the 2nd, 4th, 6th week and 1 year later （P〈0.05） compared with the baseline.Scores of HAMD in study group were significantly lower than those in control group at the end of the 4th, 6th week and 1 year later （P〈0.01）.Factor scores of positive symptom and general pathology in PANSS and total score of SDSS in both groups decreased significantly at the end of the 4th, 6th week and 1 year later when compared with the baseline （P〈0.05）.Total score of PANSS and factor score of negative symptom in both groups decreased significantly at the end of the 2nd, 4th, 6th week and 1 year later when compared with the baseline （P〈0.05）.Factor score of negative symptom and total scores of PANSS and SDSS in study group were significantly lower than those in control group at the end of the 4th, 6th week and 1 year later （P〈0.05）.Factor scores of positive symptom and general pathology in PANSS in study group were significantly lower than those in control group at the end of the 1-year follow-up （P〈0.05）.The recurrence rate in study group （7%） was significantly lower than that in control group （7%vs.25%, P〈0.05）.Conclusion Behavioral activation therapy can improve efficacy of medication for post-schizophrenia depression, reduce 1-year recurrence rate and improve the patient’s social function.
出处
《精神医学杂志》
2015年第4期281-283,共3页
Journal of Psychiatry
关键词
行为激活疗法
精神分裂症后抑郁
疗效
社会功能
Behavioral activation therapy
Post-schizophrenia depression
Efficacy
Social function
