摘要
目的 :建立HPLC法测定氨糖美辛肠溶片中吲哚美辛的含量。方法 :采用SPHERI-5Rp -1 8色谱柱 ,以甲醇 -水 -乙腈 -磷酸 (6 0∶2 5∶1 5∶0 0 4)为流动相。结果 :吲哚美辛在 1 0～ 6 0 μg/ml范围内浓度与峰面积有良好的线性关系 (r=0 9999) ,平均回收率为 99 5 6 % ,RSD为 0 6 5 %。结论 :本法准确、快速。
OBJECTIVE:To establish a method for the determination the indometacin content in glucosamine indometacin enteric-coated tablets by HPLC.METHODS:Using SPHERI-5 RP-18 column,with methanol-water-acetonitrile-phosphoric acid(60:25:15:0.04) as the mobile.RESULTS:An excellent linear relationship was obtained between the peak area and the concentration with the range of 10～60μg/ml.The average recoverary was 99.56%,the RSD was 0.65%.CONCLUSION:This method is accurate,quick and reproducible.
出处
《药学实践杂志》
CAS
2000年第2期91-92,,95,,共3页
Journal of Pharmaceutical Practice
