摘要
目的：评价地高辛抗血清对抗心肌缺氧损伤的作用与机制。方法：制备心肌组织缺氧模型，观察不同剂量的地高辛抗血清对缺氧损伤心肌组织内洋地黄素水平和心肌细胞膜ＡＴＰ酶活性的影响。结果：缺氧损伤时心肌组织内洋地黄素水平明显高于正常对照组，心肌细胞膜ＡＴＰ酶活性明显低于正常对照组；地高辛抗血清能明显拮抗缺氧对心肌细胞膜ＡＴＰ酶活性的抑制作用。结论：缺氧所致心肌组织内洋地黄素水平升高是缺氧介导心肌损伤的分子生物学基础，地高辛抗血清通过拮抗内洋地黄素的作用，减轻缺氧所致心肌损伤，对缺氧心肌具有保护作用。
AIM: To evaluate the antagonistic effect of anti - digoxin antiserum on hypoxic myocardium and its mechanism. METHODS: It was observed that different concentration of anti-digoxin antiserum effect on endoxin and cell membrane ATPase activity in hypoxic myocardium model. RESULTS: The endoxin level was much higher, cell membrane ATPase activity was much lower in hypoxic myocedium than those of noed; anti-digoxin antiserum can resume membrane ATPase activity. CONCLUSION: Rise of endoxin was basic in molecular biology of myocar- dial damage during myocardial hypoxia. Anti - digoxin antiserum decreased myocardial damge and has protective ef- fect on hypoxic myocardium by antagonistic effeCt of endoxin.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第5期418-420,共3页
Chinese Journal of Pathophysiology
关键词
心肌缺血
洋地黄素
地高辛
ATP酶
心肌细胞膜
Myocardium
Anoxia
Digitalis
Adenosine triphosphatase
sodium
potassium
Digoxin
