摘要
探讨血清内洋地黄素浓度与糖尿病之间的关系。结果表明,非胰岛素依赖型糖尿病(NIDDM)患者内洋地黄素水平为(0.49±0.16)μg/L,明显高于正常人(0.22±0.11)μg/L(P<0.01).提示内洋地黄素可能参与糖尿病患者并发心血管疾病的发病机制。并发心血管病的NID-DM患者内洋地黄素浓度为(0.52±0.18)μg/L,亦明显高于无并发症的患者(0.43±0.10)μg/L(P<0.05),进一步提示糖尿病患者容易并发心血管疾病的机制之一可能是内洋地黄素的释放增多。结果还显示,内洋地黄素水平与病程无关。内洋地黄素是通过其缩血管效应和刺激平滑肌增生作用促进糖尿病并发的心血管疾患的发生、发展。
The study investigated the relation between serum endogenous digitalis-like factor( EDLF) levels arid diabetes rnellitus. Results showed that EDLF concentrations of diabetic patients were significantly higher than these of normal subjects(0.49±0.16ng/ml vs.0.22± 0.1 Ing/ml),suggesting EDLF might participate in the pathogenesis of diabetic vasculocardiopathy. Patients complicated by cardiovascular diseases had higher EDLF value than those without(0.52 ± 0.18ng/ml vs 0.43 ± 0. l0ng/ml) , whereas EDLF levels were irrelevant to the course of disease. This further implied that one of pathogenic mechanisms which accelerated the incidence of complications of cardiovascular diseases was the increasing release of EDLF. EDLF may constrict vascular vessels and stimulate proliferation of smooth muscle, which accelerates occurrence and development of the complication.
出处
《天津医药》
CAS
1998年第5期268-270,共3页
Tianjin Medical Journal
关键词
糖尿病
并发症
内洋地黄素
NIDDM
diabetes mellitus endogenous digitalis-like factor cardiovascular diseases
