摘要
目的观察术前放化疗对保肛手术比率（保肛率）、局部复发率和术后肛门括约肌功能的影响。方法TNM分期为Ⅱ、Ⅲ期中低位直肠癌56例，在术前进行放化疗，放疗结束后6周左右接受手术治疗。另将术前未行放化疗的50例中低位进展期直肠癌作为对照组，比较两组保肛率、术后局部复发率，并对两组术后肛门排便功能进行评价。结果术前放化疗组行保肛手术48例，保肛率85．7％，术后局部复发3例（5．4％）；48例保肛手术后6个月排便功能优良率为81．3％。对照组行保肛手术36例，保肛率为72．0％，术后局部复发6例（12．0％）；36例保肛手术后6个月排便功能优良率为91．7％。术前放化疗组保肛率明显高于对照组（P〈0．05），术前放化疗组术后局部复发率明显降低（P〈0．05）。保肛手术后排便功能两组间差异无统计学意义（P〉0．05）。结论术前放化疗对进展期中低位直肠癌确实能降低肿瘤局部复发率、提高保肛成功率。
Objective To evaluate the effects of preoperative chemoradiotherapy on anorectal function and quality of life of the patients with rectal cancer after low anastomosis. Methods There were 50 patients in surgery group and 56 patients in preoperative chemoradiotherapy group. Surgical operations were performed 6 weeks after neoadjuvant therapy. The sphincter preserving surgery, ano- rectal function and quality of life of the patients were assessed. Results Forty-eight patients were sub- jected to sphincter preserving surgery in preoperative chemoradiotherapy group （85. 7 %） and the local recurrence rate was 5. 4 %. The rate of good anal function was 81.3 ~. While in surgery group,36 patients were subjected to sphincter preserving surgery （72. 0 %） and the local recurrence rate was 12 %. Conclusion Preoperative chemoradiotherapy increases the rate of sphincter preservation for advanced lower rectal cancer and decreases the local recurrent rate.
出处
《腹部外科》
2012年第3期161-163,共3页
Journal of Abdominal Surgery
关键词
直肠肿瘤
治疗
临床研究性
肿瘤复发
局部
排便
Rectal neoplasms
Therapies, investigational
Neoplasm recurrence, local
Defecation
