摘要
目的 :了解近年来重庆市区志贺菌的流行菌型。方法 :对近两年收集的 349株志贺菌进行血清学分型 ,质粒图谱分析和药敏试验。结果 :334株细菌的质粒图谱显示 :98.8%的菌株含有质粒 ,其中 2 79株福氏志贺菌共有 8种质粒 ,分为 12种质粒图谱模式。所有菌株对常用抗生素均为三重及三重以上耐药 ,且显示福氏志贺菌的多重耐药较宋内志贺菌更为严重。结论 :福氏志贺菌和宋内志贺菌是本地区当前流行的两大菌群 ,福氏 2a血清型占 93 .9% 。
Objective:The study is to research the prevalence of Shigella in Chongqing. Methods:A total of 349 strains of Shigella isolated from 1997 to 1998 in Chongqing urban district were detected for serotype and plasmid profiles as well as antibiotic resistance. Results:The plasmid profiles of 334 strains showed that 98.8% of the isolates harboured plasmid.Among them 279 Shigella flexneri harboured at least 3 and up to 8 plasmids and contained 7 distinct plasmid patterns.51 Shigella sonnei contained 12 plasmids and were typed 12 plasmid patterns.Antibiotic resistance tests demonstrated that the problem of antibiotic resistance of Shigella was very severe.All isolates had resistance to ten kinds of antibiotics in different degrees;the highest resistance was encountered to rifampin(100%),followed by tobramycin (96.4%) amikacin (95.8%) norfloxacin (91%),while the least resistance was observed to caftriazone (1.8).All strains were resistant to at least 3 antibiotics and the multiple resistance of Shigella flexneri was more serious than that of Shigella sonnei. Conclusion:According to the result,Shigella flexneri and Shigella sonnei were the two main epidemic groups in this area currently.The most predominant subtype(93.9%)was 2a serotype of B group.
出处
《重庆医科大学学报》
CAS
CSCD
2000年第2期128-130,共3页
Journal of Chongqing Medical University
关键词
志贺菌
质粒图谱
痢疾
分子流行病学
Shigella
Plasmid profile
Serotype
Antibiotic resistance test
